N V Naryzhnaya, A V Mukhomedzyanov, M Kilin, N S Voronkov, B K Kurbatov, L N Maslov
{"title":"大鼠慢性给药和饮食诱导代谢综合征条件下KATP通道激活剂和一氧化氮供体的梗死限制作用","authors":"N V Naryzhnaya, A V Mukhomedzyanov, M Kilin, N S Voronkov, B K Kurbatov, L N Maslov","doi":"10.1007/s10517-025-06421-y","DOIUrl":null,"url":null,"abstract":"<p><p>Coronary occlusion (45 min) and reperfusion (2 h) were modeled, and the ratio of the necrosis area to area at risk ratio was measured in rats. Metabolic syndrome was induced by high-carbohydrate high-fat diet for 84 days. A single administration of diazoxide, nicorandil at a dose of 5 mg/kg or nitroglycerin at a dose of 0.24 mg/kg to animals without metabolic syndrome resulted in a decrease in infarct size. A 21-day course of diazoxide had no infarct-limiting effect. After course administration of nicorandil or nitroglycerin, we observed a trend toward a decrease in infarct size, which completely disappeared 2 weeks after the course of therapy. In rats with metabolic syndrome, no infarct-limiting effect of diazoxide, nicorandil, and nitroglycerin was revealed.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"1-5"},"PeriodicalIF":0.6000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Infarct-Limiting Efficacy of K<sub>ATP</sub> Channel Activators and Nitric Oxide Donors under Conditions of Their Chronic Administration and Diet-Induced Metabolic Syndrome Conditions in Rats.\",\"authors\":\"N V Naryzhnaya, A V Mukhomedzyanov, M Kilin, N S Voronkov, B K Kurbatov, L N Maslov\",\"doi\":\"10.1007/s10517-025-06421-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Coronary occlusion (45 min) and reperfusion (2 h) were modeled, and the ratio of the necrosis area to area at risk ratio was measured in rats. Metabolic syndrome was induced by high-carbohydrate high-fat diet for 84 days. A single administration of diazoxide, nicorandil at a dose of 5 mg/kg or nitroglycerin at a dose of 0.24 mg/kg to animals without metabolic syndrome resulted in a decrease in infarct size. A 21-day course of diazoxide had no infarct-limiting effect. After course administration of nicorandil or nitroglycerin, we observed a trend toward a decrease in infarct size, which completely disappeared 2 weeks after the course of therapy. In rats with metabolic syndrome, no infarct-limiting effect of diazoxide, nicorandil, and nitroglycerin was revealed.</p>\",\"PeriodicalId\":9331,\"journal\":{\"name\":\"Bulletin of Experimental Biology and Medicine\",\"volume\":\" \",\"pages\":\"1-5\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bulletin of Experimental Biology and Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10517-025-06421-y\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/18 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Experimental Biology and Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10517-025-06421-y","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/18 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Infarct-Limiting Efficacy of KATP Channel Activators and Nitric Oxide Donors under Conditions of Their Chronic Administration and Diet-Induced Metabolic Syndrome Conditions in Rats.
Coronary occlusion (45 min) and reperfusion (2 h) were modeled, and the ratio of the necrosis area to area at risk ratio was measured in rats. Metabolic syndrome was induced by high-carbohydrate high-fat diet for 84 days. A single administration of diazoxide, nicorandil at a dose of 5 mg/kg or nitroglycerin at a dose of 0.24 mg/kg to animals without metabolic syndrome resulted in a decrease in infarct size. A 21-day course of diazoxide had no infarct-limiting effect. After course administration of nicorandil or nitroglycerin, we observed a trend toward a decrease in infarct size, which completely disappeared 2 weeks after the course of therapy. In rats with metabolic syndrome, no infarct-limiting effect of diazoxide, nicorandil, and nitroglycerin was revealed.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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