用于多种原位磷酸化Tau蛋白检测的完全集成可穿戴生物传感器。

IF 6.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Analytical Chemistry Pub Date : 2025-07-18 DOI:10.1021/acs.analchem.5c02541

Xin Sun,Geng Zhong,Yu Zeng,Tailin Xu,Yibiao Liu

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引用次数: 0

摘要

早期诊断对于预防和治疗阿尔茨海默病（AD）至关重要，因为它可以及时发现和干预。在这里，我们开发了一种完全集成的可穿戴电化学传感贴片，用于AD的早期筛查，它将样品收集和检测结合在一个设备内。这种可穿戴贴片集成了定制开发的微针采样系统和可穿戴的多模态电化学生物传感器。该微针取样系统通过微针阵列将间隙液（ISF）输送到检测区域，其中电化学传感系统可直接原位检测ad相关生物标志物P-tau181和P-tau217，检出限分别为0.058和0.079 pg/mL。此外，传感贴片还包含蓝牙模块，可以将检测结果传输到手机APP进行显示和进一步的检测控制。这种完全集成的可穿戴电化学传感贴片为早期多发性AD原位诊断提供了一种有前景的策略。

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Fully Integrated Wearable Biosensor for Multiple In Situ Phosphorylated Tau Protein Detection.

Early diagnosis is critical for the prevention and treatment of Alzheimer's disease (AD), as it allows for timely detection and intervention. Here, we developed a fully integrated wearable electrochemical sensing patch for early screening of AD, which combines sample collection and detection within a device. This wearable patch integrates a custom-developed microneedle sampling system with a wearable multimodal electrochemical biosensor. Such a microneedle sampling system can deliver interstitial fluid (ISF) to the detection area through a microneedle array, where the electrochemical sensing system can directly detect AD-related biomarkers P-tau181 and P-tau217 in situ with detection limits of 0.058 and 0.079 pg/mL. Additionally, the sensing patch includes a Bluetooth module, enabling the transmission of detection results to a mobile phone APP for display and further detection control. This fully integrated wearable electrochemical sensing patch provides a promising strategy for early multiple in situ diagnosis of AD.

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来源期刊

Analytical Chemistry 化学-分析化学

CiteScore

12.10

自引率

12.20%

发文量

1949

审稿时长

1.4 months

期刊介绍： Analytical Chemistry, a peer-reviewed research journal, focuses on disseminating new and original knowledge across all branches of analytical chemistry. Fundamental articles may explore general principles of chemical measurement science and need not directly address existing or potential analytical methodology. They can be entirely theoretical or report experimental results. Contributions may cover various phases of analytical operations, including sampling, bioanalysis, electrochemistry, mass spectrometry, microscale and nanoscale systems, environmental analysis, separations, spectroscopy, chemical reactions and selectivity, instrumentation, imaging, surface analysis, and data processing. Papers discussing known analytical methods should present a significant, original application of the method, a notable improvement, or results on an important analyte.