Sarah M Simmons, Madison Donoghue, Shannon Erdelyi, Herbert Chan, Christian Vaillancourt, Paul Atkinson, Floyd Besserer, David B Clarke, Phil Davis, Raoul Daoust, Marcel Émond, Jeffrey Eppler, Jacques S Lee, Andrew MacPherson, Kirk Magee, Eric Mercier, Robert Ohle, Michael Parsons, Jagadish Rao, Brian H Rowe, John Taylor, Ian Wishart, Jeffrey R Brubacher
{"title":"大麻和酒精对加拿大创伤中心机动车伤害严重程度的影响：一项前瞻性研究。","authors":"Sarah M Simmons, Madison Donoghue, Shannon Erdelyi, Herbert Chan, Christian Vaillancourt, Paul Atkinson, Floyd Besserer, David B Clarke, Phil Davis, Raoul Daoust, Marcel Émond, Jeffrey Eppler, Jacques S Lee, Andrew MacPherson, Kirk Magee, Eric Mercier, Robert Ohle, Michael Parsons, Jagadish Rao, Brian H Rowe, John Taylor, Ian Wishart, Jeffrey R Brubacher","doi":"10.1136/ip-2025-045642","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Alcohol and delta-9-tetrahydrocannabinol (THC) (main impairing ingredient of cannabis) are both crash contributors that interfere with motor vehicle operation. However, the relationship between drug concentration and crash injury severity is unclear for either drug. We aim to clarify the relationship between blood alcohol concentration (BAC) and crash injury severity, based on healthcare system utilisation, with and without THC.</p><p><strong>Methods: </strong>The National Drug Driving Study is an ongoing prospective study involving 17 Canadian trauma centres. Eligible subjects included drivers aged 16+ who visited a participating trauma centre and had blood drawn as part of routine care within 6 hours of a crash. Deidentified blood samples were tested for alcohol and THC using gas chromatography-flame ionisation detection and liquid chromatography/tandem mass spectrometry. Study outcomes included admission to hospital and admitted patients' length of hospital stay.</p><p><strong>Results: </strong>10 322 injured drivers visited a participating trauma centre between 2018 and 2023. 1649 (16.0%), 1716 (16.6%) and 463 (4.5%) drivers had detectable levels of alcohol, THC or both, respectively. Compared with sober drivers (BAC=0), drivers with 0%<BAC<0.08% had increased odds of admission (aOR=1.69, 95% CI=1.31 to 2.19), as did drivers with BAC≥0.08% (aOR=1.36, 95% CI=1.16 to 1.60). THC did not modify the relationship between alcohol and admission. Neither alcohol nor THC predicted were associated with length of stay following admission.</p><p><strong>Interpretation: </strong>Alcohol increases hospital admissions after crashes but does not have a dose-response relationship with admission or length of stay. THC does not moderate this relationship.</p>","PeriodicalId":520647,"journal":{"name":"Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Influence of cannabis and alcohol on motor vehicle injury severity in Canadian trauma centres: a prospective study.\",\"authors\":\"Sarah M Simmons, Madison Donoghue, Shannon Erdelyi, Herbert Chan, Christian Vaillancourt, Paul Atkinson, Floyd Besserer, David B Clarke, Phil Davis, Raoul Daoust, Marcel Émond, Jeffrey Eppler, Jacques S Lee, Andrew MacPherson, Kirk Magee, Eric Mercier, Robert Ohle, Michael Parsons, Jagadish Rao, Brian H Rowe, John Taylor, Ian Wishart, Jeffrey R Brubacher\",\"doi\":\"10.1136/ip-2025-045642\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Alcohol and delta-9-tetrahydrocannabinol (THC) (main impairing ingredient of cannabis) are both crash contributors that interfere with motor vehicle operation. However, the relationship between drug concentration and crash injury severity is unclear for either drug. We aim to clarify the relationship between blood alcohol concentration (BAC) and crash injury severity, based on healthcare system utilisation, with and without THC.</p><p><strong>Methods: </strong>The National Drug Driving Study is an ongoing prospective study involving 17 Canadian trauma centres. Eligible subjects included drivers aged 16+ who visited a participating trauma centre and had blood drawn as part of routine care within 6 hours of a crash. Deidentified blood samples were tested for alcohol and THC using gas chromatography-flame ionisation detection and liquid chromatography/tandem mass spectrometry. Study outcomes included admission to hospital and admitted patients' length of hospital stay.</p><p><strong>Results: </strong>10 322 injured drivers visited a participating trauma centre between 2018 and 2023. 1649 (16.0%), 1716 (16.6%) and 463 (4.5%) drivers had detectable levels of alcohol, THC or both, respectively. Compared with sober drivers (BAC=0), drivers with 0%<BAC<0.08% had increased odds of admission (aOR=1.69, 95% CI=1.31 to 2.19), as did drivers with BAC≥0.08% (aOR=1.36, 95% CI=1.16 to 1.60). THC did not modify the relationship between alcohol and admission. Neither alcohol nor THC predicted were associated with length of stay following admission.</p><p><strong>Interpretation: </strong>Alcohol increases hospital admissions after crashes but does not have a dose-response relationship with admission or length of stay. THC does not moderate this relationship.</p>\",\"PeriodicalId\":520647,\"journal\":{\"name\":\"Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1136/ip-2025-045642\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1136/ip-2025-045642","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Influence of cannabis and alcohol on motor vehicle injury severity in Canadian trauma centres: a prospective study.
Background: Alcohol and delta-9-tetrahydrocannabinol (THC) (main impairing ingredient of cannabis) are both crash contributors that interfere with motor vehicle operation. However, the relationship between drug concentration and crash injury severity is unclear for either drug. We aim to clarify the relationship between blood alcohol concentration (BAC) and crash injury severity, based on healthcare system utilisation, with and without THC.
Methods: The National Drug Driving Study is an ongoing prospective study involving 17 Canadian trauma centres. Eligible subjects included drivers aged 16+ who visited a participating trauma centre and had blood drawn as part of routine care within 6 hours of a crash. Deidentified blood samples were tested for alcohol and THC using gas chromatography-flame ionisation detection and liquid chromatography/tandem mass spectrometry. Study outcomes included admission to hospital and admitted patients' length of hospital stay.
Results: 10 322 injured drivers visited a participating trauma centre between 2018 and 2023. 1649 (16.0%), 1716 (16.6%) and 463 (4.5%) drivers had detectable levels of alcohol, THC or both, respectively. Compared with sober drivers (BAC=0), drivers with 0%
Interpretation: Alcohol increases hospital admissions after crashes but does not have a dose-response relationship with admission or length of stay. THC does not moderate this relationship.
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