放射治疗中的性别差异：一项重要综述。

IF 5.5 2区医学 Q1 HEMATOLOGY

Critical reviews in oncology/hematology Pub Date : 2025-07-12 DOI:10.1016/j.critrevonc.2025.104843

Emma D'Ippolito , Roberta Grassi , Cristiano Grossi , Imma Vivone , Giusepina Iaquinto , Viola Salvestrini , Francesca De Felice , Luca Boldrini , Antonio Piras , Isacco Desideri , Giuseppe Carlo Iorio , Valerio Nardone

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引用次数: 0

摘要

放疗是一种有效的抗癌手段。放射敏感性因人而异。虽然性别之间的放射敏感性差异已被充分记录，但大多数放射治疗指南和临床试验并未考虑到这一重要的性别/性别因素。材料和方法：主要参考文献来源于PubMed查询。手工搜索和clinicaltrials.gov也被使用。结果：本文包含一个叙述性的报告和一个关键的讨论，目前的证据关于性别和放疗之间的相互作用，在治疗耐受性和疗效方面。结论：个性化治疗方法和性别意识临床试验是优化患者护理和实现公平结果的必要条件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Gender differences in radiotherapy: A critical review

Introduction

Radiotherapy is an effective anticancer agent. Radiosensitivity varies between individuals. While disparities in radiosensitivity between sex have been well documented, most radiotherapy guidelines and clinical trials do not take into account this important sex/gender factor.

Materials and methods

Key references were derived from a PubMed query. Hand searching and clinicaltrials.gov were also used.

Results

This paper contains a narrative report and a critical discussion of the current evidence regarding the interplay between gender and radiotherapy in terms of both treatment tolerance and efficacy.

Conclusions

Personalized treatment approaches and gender-aware clinical trials are essential to optimize patient care and achieve equitable outcomes.

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来源期刊

Critical reviews in oncology/hematology 医学-血液学

CiteScore

11.00

自引率

3.20%

发文量

213

审稿时长

55 days

期刊介绍： Critical Reviews in Oncology/Hematology publishes scholarly, critical reviews in all fields of oncology and hematology written by experts from around the world. Critical Reviews in Oncology/Hematology is the Official Journal of the European School of Oncology (ESO) and the International Society of Liquid Biopsy.