{"title":"既往房颤患者行分离二尖瓣手术伴或不伴手术消融的趋势和早期临床结果","authors":"Jeremy Chan, Saifullah Mohamed, Gianni D Angelini","doi":"10.1177/02676591251361352","DOIUrl":null,"url":null,"abstract":"<p><p>IntroductionEuropean and American guidelines recommend concomitant surgical ablation for atrial fibrillation (AF) in patients undergoing mitral valve surgery. There is evidence that this intervention reduces the incidence of early and mid-term incidence of AF post-operatively. We aim to report the trend and early clinical outcomes in this cohort of patients in the United Kingdom.MethodThis study included all patients with underlying atrial fibrillation who underwent first-time, elective, or urgent isolated mitral valve repair/replacement from 2011 to April 2019. We evaluated the trend and early clinical outcomes between patients who did/did not receive surgical AF ablation and examined associated factors.ResultsA total of 3497 patients were included, with a median age of 70.6 years old (IQR: 63.1, 76.5), and 52.67% were male. The number of isolated mitral valve surgery performed ranges between 388 to 464 during the study period. The mitral valve repair rate was 62%. The overall AF ablation rate was 27.71% (Range: 16.74%-33.33%). After inverse propensity score matching, patients who underwent AF ablation had a significantly longer cardiopulmonary bypass (125 vs 99 mins, <i>p</i> < .001) and aortic cross-clamp time (92 vs 73 mins, <i>p</i> < .001). However, there was no difference in in-hospital mortality (2.03% vs 1.80%, <i>p</i> = .69), return to theatre for bleeding (5.82% vs 7.44%, <i>p</i> = .11), post-operative stroke (0.61% vs 0.48%, <i>p</i> = .11), post-operative dialysis (2.54% vs 2.40%, <i>p</i> = .83) and deep sternal wound infection (0.56% vs 0.88%, <i>p</i> = .34).ConclusionPatients with pre-existing atrial fibrillation undergoing concomitant surgical ablation during mitral valve intervention had a longer cardiopulmonary bypass and cross-clamp time without compromising short-term clinical outcomes. Long-term outcomes are required to examine the potential lasting benefit of surgical ablation.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"2676591251361352"},"PeriodicalIF":1.1000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Trend and early clinical outcomes in patients with preexisting atrial fibrillation undergoing isolated mitral valve surgery with or without surgical ablation.\",\"authors\":\"Jeremy Chan, Saifullah Mohamed, Gianni D Angelini\",\"doi\":\"10.1177/02676591251361352\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>IntroductionEuropean and American guidelines recommend concomitant surgical ablation for atrial fibrillation (AF) in patients undergoing mitral valve surgery. There is evidence that this intervention reduces the incidence of early and mid-term incidence of AF post-operatively. We aim to report the trend and early clinical outcomes in this cohort of patients in the United Kingdom.MethodThis study included all patients with underlying atrial fibrillation who underwent first-time, elective, or urgent isolated mitral valve repair/replacement from 2011 to April 2019. We evaluated the trend and early clinical outcomes between patients who did/did not receive surgical AF ablation and examined associated factors.ResultsA total of 3497 patients were included, with a median age of 70.6 years old (IQR: 63.1, 76.5), and 52.67% were male. The number of isolated mitral valve surgery performed ranges between 388 to 464 during the study period. The mitral valve repair rate was 62%. The overall AF ablation rate was 27.71% (Range: 16.74%-33.33%). After inverse propensity score matching, patients who underwent AF ablation had a significantly longer cardiopulmonary bypass (125 vs 99 mins, <i>p</i> < .001) and aortic cross-clamp time (92 vs 73 mins, <i>p</i> < .001). However, there was no difference in in-hospital mortality (2.03% vs 1.80%, <i>p</i> = .69), return to theatre for bleeding (5.82% vs 7.44%, <i>p</i> = .11), post-operative stroke (0.61% vs 0.48%, <i>p</i> = .11), post-operative dialysis (2.54% vs 2.40%, <i>p</i> = .83) and deep sternal wound infection (0.56% vs 0.88%, <i>p</i> = .34).ConclusionPatients with pre-existing atrial fibrillation undergoing concomitant surgical ablation during mitral valve intervention had a longer cardiopulmonary bypass and cross-clamp time without compromising short-term clinical outcomes. Long-term outcomes are required to examine the potential lasting benefit of surgical ablation.</p>\",\"PeriodicalId\":49707,\"journal\":{\"name\":\"Perfusion-Uk\",\"volume\":\" \",\"pages\":\"2676591251361352\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2025-07-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Perfusion-Uk\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/02676591251361352\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Perfusion-Uk","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/02676591251361352","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
摘要
欧洲和美国的指南推荐二尖瓣手术患者心房颤动(AF)的联合手术消融。有证据表明,这种干预降低了术后AF的早期和中期发病率。我们的目标是报告英国这组患者的趋势和早期临床结果。方法:本研究纳入2011年至2019年4月期间接受首次、选择性或紧急孤立性二尖瓣修复/置换术的所有潜在心房颤动患者。我们评估了接受/未接受手术房颤消融的患者的趋势和早期临床结果,并检查了相关因素。结果共纳入3497例患者,中位年龄70.6岁(IQR: 63.1, 76.5),男性占52.67%。在研究期间,孤立二尖瓣手术的数量在388到464之间。二尖瓣修复率为62%。总房颤消融率为27.71%(16.74% ~ 33.33%)。经反向倾向评分匹配后,接受房颤消融的患者体外循环时间(125 vs 99分钟,p < 0.001)和主动脉交叉夹夹时间(92 vs 73分钟,p < 0.001)显著延长。然而,两组在住院死亡率(2.03% vs 1.80%, p = 0.69)、因出血返回手术室(5.82% vs 7.44%, p = 0.11)、术后卒中(0.61% vs 0.48%, p = 0.11)、术后透析(2.54% vs 2.40%, p = 0.83)和胸骨深部伤口感染(0.56% vs 0.88%, p = 0.34)方面无差异。结论既往房颤患者在二尖瓣介入手术中合并手术消融可延长体外循环和交叉夹持时间,但不影响短期临床效果。需要长期结果来检验手术消融的潜在持久益处。
Trend and early clinical outcomes in patients with preexisting atrial fibrillation undergoing isolated mitral valve surgery with or without surgical ablation.
IntroductionEuropean and American guidelines recommend concomitant surgical ablation for atrial fibrillation (AF) in patients undergoing mitral valve surgery. There is evidence that this intervention reduces the incidence of early and mid-term incidence of AF post-operatively. We aim to report the trend and early clinical outcomes in this cohort of patients in the United Kingdom.MethodThis study included all patients with underlying atrial fibrillation who underwent first-time, elective, or urgent isolated mitral valve repair/replacement from 2011 to April 2019. We evaluated the trend and early clinical outcomes between patients who did/did not receive surgical AF ablation and examined associated factors.ResultsA total of 3497 patients were included, with a median age of 70.6 years old (IQR: 63.1, 76.5), and 52.67% were male. The number of isolated mitral valve surgery performed ranges between 388 to 464 during the study period. The mitral valve repair rate was 62%. The overall AF ablation rate was 27.71% (Range: 16.74%-33.33%). After inverse propensity score matching, patients who underwent AF ablation had a significantly longer cardiopulmonary bypass (125 vs 99 mins, p < .001) and aortic cross-clamp time (92 vs 73 mins, p < .001). However, there was no difference in in-hospital mortality (2.03% vs 1.80%, p = .69), return to theatre for bleeding (5.82% vs 7.44%, p = .11), post-operative stroke (0.61% vs 0.48%, p = .11), post-operative dialysis (2.54% vs 2.40%, p = .83) and deep sternal wound infection (0.56% vs 0.88%, p = .34).ConclusionPatients with pre-existing atrial fibrillation undergoing concomitant surgical ablation during mitral valve intervention had a longer cardiopulmonary bypass and cross-clamp time without compromising short-term clinical outcomes. Long-term outcomes are required to examine the potential lasting benefit of surgical ablation.
期刊介绍:
Perfusion is an ISI-ranked, peer-reviewed scholarly journal, which provides current information on all aspects of perfusion, oxygenation and biocompatibility and their use in modern cardiac surgery. The journal is at the forefront of international research and development and presents an appropriately multidisciplinary approach to perfusion science.