剪接抑制过早裂解和聚腺苷酸化。

IF 13.6 2区生物学 Q1 GENETICS & HEREDITY

Trends in Genetics Pub Date : 2025-07-11 DOI:10.1016/j.tig.2025.06.011

Sheng Yang, Mengzhao Li, Chengguo Yao

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引用次数: 0

摘要

小核核糖核蛋白（snRNPs） U1/U2/U4/U6是剪接体的关键成分。最近的研究表明，它们中的每一个都在抑制全局PCPA（过早切割和聚腺苷酸化）中发挥作用，从而支持剪接过程抑制PCPA的假设。在这篇论坛文章中，我们总结了证据来加强这一假设，并设想了潜在的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Splicing inhibits premature cleavage and polyadenylation.

Small nuclear ribonucleoproteins (snRNPs) U1/U2/U4/U6 are critical constituents of the spliceosome. Recent studies showed that each of them exhibits a role in the inhibition of global PCPA (premature cleavage and polyadenylation), thereby supporting the hypothesis that the splicing process inhibits PCPA. In this forum article we summarize evidence to reinforce this hypothesis and envision potential mechanisms.

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来源期刊

Trends in Genetics 生物-遗传学

CiteScore

20.90

自引率

0.90%

发文量

160

审稿时长

6-12 weeks

期刊介绍： Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology. Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.