同种异体不变性自然杀伤细胞对重度预处理生殖细胞肿瘤的挽救性治疗。

IF 6.9 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Oncogene Pub Date : 2025-07-10 DOI:10.1038/s41388-025-03491-0

Benjamin Garmezy, Joseph E Grossman, Jennifer Buell, Thiago Favano, Justin Stebbing, Steven O'Day, Marco A Purbhoo, Dhan Chand, F Anthony Greco

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引用次数: 0

摘要

不变自然杀伤T （iNKT）细胞，以前被认为是组织常驻细胞，是一种新兴的多功能异体细胞疗法，具有强大的抗肿瘤活性，在先天和适应性免疫反应之间相互作用。我们报告了使用体外扩增异体iNKT细胞在大量预处理的转移性生殖细胞肿瘤中前所未有的完全缓解，值得进一步的试验。

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Salvage therapy with allogeneic invariant natural killer cells in a heavily pre-treated germ cell tumor.

Invariant natural killer T (iNKT) cells, previously considered to be tissue-resident, are an emerging and versatile allogeneic cell therapy with potent anti-tumor activity, acting at the interplay between innate and adaptive immune responses. We report an unprecedented complete remission in a heavily pre-treated metastatic germ cell neoplasm, using ex vivo expanded allogeneic iNKT cells, warranting further trials.

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来源期刊

Oncogene 医学-生化与分子生物学

CiteScore

15.30

自引率

1.20%

发文量

404

审稿时长

1 months

期刊介绍： Oncogene is dedicated to advancing our understanding of cancer processes through the publication of exceptional research. The journal seeks to disseminate work that challenges conventional theories and contributes to establishing new paradigms in the etio-pathogenesis, diagnosis, treatment, or prevention of cancers. Emphasis is placed on research shedding light on processes driving metastatic spread and providing crucial insights into cancer biology beyond existing knowledge. Areas covered include the cellular and molecular biology of cancer, resistance to cancer therapies, and the development of improved approaches to enhance survival. Oncogene spans the spectrum of cancer biology, from fundamental and theoretical work to translational, applied, and clinical research, including early and late Phase clinical trials, particularly those with biologic and translational endpoints.