评价8Spheres微球联合125碘粒子治疗晚期肺鳞癌咯血的疗效:回顾性研究

IF 3.2 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Linhao Ran , Huan Liang , Jiangwei Chen , Weichen Fu , Dichun Yang , Fan Li , Li Jiang , Ying Liu
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引用次数: 0

摘要

背景:咯血是晚期肺鳞状细胞癌(LUSC)的重要并发症。本研究旨在评价8Spheres微球栓塞联合125碘粒子植入治疗晚期LUSC咯血的有效性和安全性。方法对45例晚期鳞状细胞癌伴咯血患者进行回顾性分析。主要终点包括栓塞后24小时内的咯血控制率、无咯血生存期(HFS)和总生存期(OS)。次要终点包括无进展生存期(PFS)和并发症的发生。结果技术成功率为100%。8Spheres微球栓塞后24 h内,31例患者咯血完全消除,其余患者咯血量减少70%以上。所有患者的中位HFS、中位OS和中位PFS分别为16个月、15个月和10个月。术后继续免疫治疗的患者在中位HFS、中位OS和中位PFS方面均有显著改善(中位HFS:未达到vs. 10个月,P = 0.008;中位OS: 16个月vs. 11个月,P <;0.001;中位PFS: 12个月vs. 7个月,P = 0.003)。术前使用支气管动脉CTA显像可显著缩短手术时间(42.69±8.49比64.81±7.55,P <;0.05)。术后不良反应轻微,经对症治疗后逐渐消退。结论8Spheres微球栓塞联合碘125粒子植入治疗晚期肺鳞癌咯血是一种安全有效的治疗方法,是一种有前景的治疗方案。此外,术前CTA检查可以显著缩短手术时间,而持续的免疫治疗可能有助于延缓肿瘤进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluating the efficacy of 8Spheres microsphere combined with Iodine-125 seeds in the treatment of advanced lung squamous cell carcinoma presenting with hemoptysis: A retrospective study

Background

Hemoptysis is a critical complication in advanced lung squamous cell carcinoma (LUSC). This study aims to evaluate the effectiveness and safety of 8Spheres microspheres embolization combined with iodine-125 seed implantation for managing hemoptysis in patients with advanced LUSC.

Methods

A retrospective analysis was performed involving 45 patients diagnosed with advanced squamous cell carcinoma and experiencing hemoptysis. The primary endpoints included the control rate of hemoptysis within 24 h post-embolization, hemoptysis-free survival (HFS), and overall survival (OS). Secondary endpoints comprised progression-free survival (PFS) and the occurrence of complications.

Results

The technical success rate was 100 %. Within 24 h following the 8Spheres microspheres embolization, hemoptysis was completely resolved in 31 patients, while the remaining patients showed a reduction of over 70 % in hemoptysis volume. The median HFS, median OS, and median PFS of all patients were 16 months, 15 months, and 10 months, respectively. Patients who continued with immunotherapy after the procedure demonstrated significant improvements in median HFS, median OS, and median PFS (median HFS: not reached vs. 10 months, P = 0.008; median OS: 16 months vs. 11 months, P < 0.001; median PFS: 12 months vs. 7 months, P = 0.003). The use of preoperative bronchial artery CTA imaging was shown to significantly decrease operative time (42.69 ± 8.49 vs. 64.81 ± 7.55, P < 0.05). Postoperative adverse reactions were mild and subsided with symptomatic treatment.

Conclusion

The combination of 8Spheres microspheres embolization and iodine-125 seed implantation is an effective and safe approach for managing hemoptysis in advanced lung squamous cell carcinoma, representing a promising therapeutic option for affected patients. Furthermore, preoperative CTA examination can significantly shorten operative time, while ongoing immunotherapy may help delay tumor progression.
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来源期刊
CiteScore
6.70
自引率
3.00%
发文量
398
审稿时长
42 days
期刊介绍: European Journal of Radiology is an international journal which aims to communicate to its readers, state-of-the-art information on imaging developments in the form of high quality original research articles and timely reviews on current developments in the field. Its audience includes clinicians at all levels of training including radiology trainees, newly qualified imaging specialists and the experienced radiologist. Its aim is to inform efficient, appropriate and evidence-based imaging practice to the benefit of patients worldwide.
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