Mathijs T. Rosbergen, Pieter van der Veere, Jacqueline J. Claus, Tavia E. Evans, Vikram Venkatraghavan, Frederik Barkhof, Argonde C. van Harten, M. Arfan Ikram, Wiesje M. van der Flier, Meike W. Vernooij, Frank J. Wolters
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We assessed volumes of subcortical structures on magnetic resonance imaging and determined 5-year dementia risk using Cox models.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Of 7076 participants (mean age: 66–69 years, 58.8%–61.0% women; <i>N</i><sub>SCC</sub> = 5425, <i>N</i><sub>MCI</sub> = 1661), 622 developed dementia within 5 years. Smaller volumes of the hippocampus and amygdala were consistently associated with increased dementia risk, independent of other subcortical structures. Smaller hippocampal volume was predominantly associated with the clinical diagnosis of Alzheimer's disease, but the prognostic value did not differ by amyloid status.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>Hippocampal and amygdalar volume are consistently associated with dementia risk in individuals with subjective cognitive decline or mild cognitive impairment, which may hold potential for personalized prognosis.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Seven thousand seventy-six participants from three large longitudinal cohorts were followed for a maximum of 5 years.</li>\n \n <li>Hippocampal volume is associated with 5-year risk of dementia in subjective cognitive decline (SCD) or mild cognitive impairment (MCI).</li>\n \n <li>Amygdalar volume is associated with a 5-year risk of dementia in SCD or MCI.</li>\n \n <li>Stratifying by SCD and MCI revealed no consistent major differences.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 7","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70413","citationCount":"0","resultStr":"{\"title\":\"Subcortical gray matter volumes and 5-year dementia risk in individuals with subjective cognitive decline or mild cognitive impairment: A multi-cohort analysis\",\"authors\":\"Mathijs T. 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Subcortical gray matter volumes and 5-year dementia risk in individuals with subjective cognitive decline or mild cognitive impairment: A multi-cohort analysis
INTRODUCTION
The prognostic value of subcortical gray matter structures for dementia beyond the hippocampus remains unclear.
METHODS
We included participants with subjective cognitive decline or mild cognitive impairment from two memory clinic-based cohorts (Amsterdam Dementia Cohort and National Alzheimer's Coordinating Center) and one population-based cohort (Rotterdam Study). We assessed volumes of subcortical structures on magnetic resonance imaging and determined 5-year dementia risk using Cox models.
RESULTS
Of 7076 participants (mean age: 66–69 years, 58.8%–61.0% women; NSCC = 5425, NMCI = 1661), 622 developed dementia within 5 years. Smaller volumes of the hippocampus and amygdala were consistently associated with increased dementia risk, independent of other subcortical structures. Smaller hippocampal volume was predominantly associated with the clinical diagnosis of Alzheimer's disease, but the prognostic value did not differ by amyloid status.
DISCUSSION
Hippocampal and amygdalar volume are consistently associated with dementia risk in individuals with subjective cognitive decline or mild cognitive impairment, which may hold potential for personalized prognosis.
Highlights
Seven thousand seventy-six participants from three large longitudinal cohorts were followed for a maximum of 5 years.
Hippocampal volume is associated with 5-year risk of dementia in subjective cognitive decline (SCD) or mild cognitive impairment (MCI).
Amygdalar volume is associated with a 5-year risk of dementia in SCD or MCI.
Stratifying by SCD and MCI revealed no consistent major differences.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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