Dimitri B. A. Mantovani, Laura C. Oliveira, Lidia E. W. Spelta, Claudia L. Carvalho, Orestes V. Forlenza, Suely K. N. Marie, Carlos A. Buchpiguel, Artur M. Coutinho, Daniele de Paula Faria
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Voxel-wise and region-based analyses were conducted, and associations between [<sup>11</sup>C]PK11195 binding and Aβ load were investigated.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Individuals with DS exhibited increased [<sup>11</sup>C]PK11195 binding compared to non-DS controls, with most pronounced differences in older (≥50 years) adults, followed by younger (20–34 years), and intermediate (35–49 years) ages. Among DS participants, 13 individuals were amyloid positive. 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Neuroinflammation and amyloid load in different age groups of individuals with Down syndrome: A PET imaging study
INTRODUCTION
Down syndrome (DS) is associated with early-onset Alzheimer's disease (AD). This study evaluated neuroinflammation and amyloid beta (Aβ) load in individuals with DS of different ages, using positron emission tomography (PET) imaging.
METHODS
DS (n = 29) and age-matched non-DS (n = 35) individuals underwent [11C]PK11195 and [11C]PiB (Pittsburgh compound B) PET scans, for assessment of neuroinflammation and Aβ load, respectively. Voxel-wise and region-based analyses were conducted, and associations between [11C]PK11195 binding and Aβ load were investigated.
RESULTS
Individuals with DS exhibited increased [11C]PK11195 binding compared to non-DS controls, with most pronounced differences in older (≥50 years) adults, followed by younger (20–34 years), and intermediate (35–49 years) ages. Among DS participants, 13 individuals were amyloid positive. Associations were observed between [11C]PK11195 binding and global Aβ load.
DISCUSSION
Neuroinflammation in DS follows a region-specific pattern, partially associated with amyloid deposition, and may contribute to the early progression of AD-related pathology.
Highlights
Neuroinflammation is elevated in Down syndrome (DS) versus age-matched non-DS controls.
Neuroinflammation in DS shows a different pattern depending on the brain region.
[11C]PK11195 uptake has a positive monotonic association with amyloid burden.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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