Linden C Penner, Jason B Tabor, Joel S Burma, Heather Godfrey, Jean-Michel Galarneau, Jennifer Gradi Cooper, Mohammad Ghodsi, Cheryl L Wellington, Chantel T Debert, Carolyn A Emery, Jonathan D Smirl
{"title":"间歇运动和日变化对运动相关脑震荡血液生物标志物的影响：一项交叉队列研究","authors":"Linden C Penner, Jason B Tabor, Joel S Burma, Heather Godfrey, Jean-Michel Galarneau, Jennifer Gradi Cooper, Mohammad Ghodsi, Cheryl L Wellington, Chantel T Debert, Carolyn A Emery, Jonathan D Smirl","doi":"10.1016/j.jsams.2025.06.008","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Preliminary investigation of exercise and diurnal effects on neurofilament light, glial fibrillary acidic protein, ubiquitin carboxy-terminal hydrolase L1 and total tau.</p><p><strong>Methods: </strong>Plasma biomarkers were assayed from blood drawn before, during, immediately following, and 1, 2, 4, 6, 8, 24, and 48-h following three exercise conditions completed on a cycle ergometer (control [stationary], moderate intensity interval training and high intensity interval training). Participants with no prior concussion history completed each condition randomized four weeks apart.</p><p><strong>Design: </strong>Observational, crossover cohort.</p><p><strong>Results: </strong>Two-hundred-and-ninety-three plasma specimens from 10 participants (7 female, 3 male; median age 23.79 years (interquartile range: 21.38, 25.12)) demonstrated transient decreases in neurofilament light immediately following moderate (-1.11 pg/mL, 95 % confidence interval: -2.08 to -0.13, p = 0.03) and high intensity interval exercise (-1.48 pg/mL, 95 % confidence interval: -2.54 to -0.42, p = 0.01). Glial fibrillary acidic protein also decreased immediately following moderate (-16.47 pg/mL, 95% confidence interval: -28.88 to -4.06, p = 0.01) and high intensity interval exercise (-22.85 pg/mL, 95 % confidence interval: -30.25 to -15.45, p < 0.01), returning to control levels by 1 h post-exercise. Total tau declined throughout the day across all conditions on average (8 h: -1.15 pg/mL, β: 0.63, 95 % confidence interval: 0.44 to 0.89, p < 0.001).</p><p><strong>Conclusions: </strong>These preliminary findings highlight potential considerations for future sport-related concussion biomarker investigations collecting acute post-injury data in a sports context, as exercise may have immediate transient effects, and diurnal variations may affect plasma concentrations. Future research is needed to examine blood biomarkers affected by exercise and sport-related concussion in populations with consideration for concussion history, age, and sex.</p>","PeriodicalId":16992,"journal":{"name":"Journal of science and medicine in sport","volume":" ","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of interval exercise and diurnal variation on blood biomarkers for sport-related concussion: A crossover cohort study.\",\"authors\":\"Linden C Penner, Jason B Tabor, Joel S Burma, Heather Godfrey, Jean-Michel Galarneau, Jennifer Gradi Cooper, Mohammad Ghodsi, Cheryl L Wellington, Chantel T Debert, Carolyn A Emery, Jonathan D Smirl\",\"doi\":\"10.1016/j.jsams.2025.06.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Preliminary investigation of exercise and diurnal effects on neurofilament light, glial fibrillary acidic protein, ubiquitin carboxy-terminal hydrolase L1 and total tau.</p><p><strong>Methods: </strong>Plasma biomarkers were assayed from blood drawn before, during, immediately following, and 1, 2, 4, 6, 8, 24, and 48-h following three exercise conditions completed on a cycle ergometer (control [stationary], moderate intensity interval training and high intensity interval training). Participants with no prior concussion history completed each condition randomized four weeks apart.</p><p><strong>Design: </strong>Observational, crossover cohort.</p><p><strong>Results: </strong>Two-hundred-and-ninety-three plasma specimens from 10 participants (7 female, 3 male; median age 23.79 years (interquartile range: 21.38, 25.12)) demonstrated transient decreases in neurofilament light immediately following moderate (-1.11 pg/mL, 95 % confidence interval: -2.08 to -0.13, p = 0.03) and high intensity interval exercise (-1.48 pg/mL, 95 % confidence interval: -2.54 to -0.42, p = 0.01). Glial fibrillary acidic protein also decreased immediately following moderate (-16.47 pg/mL, 95% confidence interval: -28.88 to -4.06, p = 0.01) and high intensity interval exercise (-22.85 pg/mL, 95 % confidence interval: -30.25 to -15.45, p < 0.01), returning to control levels by 1 h post-exercise. Total tau declined throughout the day across all conditions on average (8 h: -1.15 pg/mL, β: 0.63, 95 % confidence interval: 0.44 to 0.89, p < 0.001).</p><p><strong>Conclusions: </strong>These preliminary findings highlight potential considerations for future sport-related concussion biomarker investigations collecting acute post-injury data in a sports context, as exercise may have immediate transient effects, and diurnal variations may affect plasma concentrations. Future research is needed to examine blood biomarkers affected by exercise and sport-related concussion in populations with consideration for concussion history, age, and sex.</p>\",\"PeriodicalId\":16992,\"journal\":{\"name\":\"Journal of science and medicine in sport\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-06-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of science and medicine in sport\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jsams.2025.06.008\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"SPORT SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of science and medicine in sport","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jsams.2025.06.008","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SPORT SCIENCES","Score":null,"Total":0}
Effects of interval exercise and diurnal variation on blood biomarkers for sport-related concussion: A crossover cohort study.
Objectives: Preliminary investigation of exercise and diurnal effects on neurofilament light, glial fibrillary acidic protein, ubiquitin carboxy-terminal hydrolase L1 and total tau.
Methods: Plasma biomarkers were assayed from blood drawn before, during, immediately following, and 1, 2, 4, 6, 8, 24, and 48-h following three exercise conditions completed on a cycle ergometer (control [stationary], moderate intensity interval training and high intensity interval training). Participants with no prior concussion history completed each condition randomized four weeks apart.
Design: Observational, crossover cohort.
Results: Two-hundred-and-ninety-three plasma specimens from 10 participants (7 female, 3 male; median age 23.79 years (interquartile range: 21.38, 25.12)) demonstrated transient decreases in neurofilament light immediately following moderate (-1.11 pg/mL, 95 % confidence interval: -2.08 to -0.13, p = 0.03) and high intensity interval exercise (-1.48 pg/mL, 95 % confidence interval: -2.54 to -0.42, p = 0.01). Glial fibrillary acidic protein also decreased immediately following moderate (-16.47 pg/mL, 95% confidence interval: -28.88 to -4.06, p = 0.01) and high intensity interval exercise (-22.85 pg/mL, 95 % confidence interval: -30.25 to -15.45, p < 0.01), returning to control levels by 1 h post-exercise. Total tau declined throughout the day across all conditions on average (8 h: -1.15 pg/mL, β: 0.63, 95 % confidence interval: 0.44 to 0.89, p < 0.001).
Conclusions: These preliminary findings highlight potential considerations for future sport-related concussion biomarker investigations collecting acute post-injury data in a sports context, as exercise may have immediate transient effects, and diurnal variations may affect plasma concentrations. Future research is needed to examine blood biomarkers affected by exercise and sport-related concussion in populations with consideration for concussion history, age, and sex.
期刊介绍：
The Journal of Science and Medicine in Sport is the official journal of Sports Medicine Australia (SMA) and is an an international refereed research publication covering all aspects of sport science and medicine.
The Journal considers for publication Original research and Review papers in the sub-disciplines relating generally to the broad sports medicine and sports science fields: sports medicine, sports injury (including injury epidemiology and injury prevention), physiotherapy, podiatry, physical activity and health, sports science, biomechanics, exercise physiology, motor control and learning, sport and exercise psychology, sports nutrition, public health (as relevant to sport and exercise), and rehabilitation and injury management. Manuscripts with an interdisciplinary perspective with specific applications to sport and exercise and its interaction with health will also be considered.
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