氧乙烷:天然产物的形成、反应性和全合成。

IF 2.2 4区 化学 Q2 CHEMISTRY, ORGANIC
Beilstein Journal of Organic Chemistry Pub Date : 2025-06-27 eCollection Date: 2025-01-01 DOI:10.3762/bjoc.21.101
Peter Gabko, Martin Kalník, Maroš Bella
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引用次数: 0

摘要

氧乙烷是一种4元环单醚,在药物化学中有重要的应用,可以作为宝石二甲基和羰基的极性和代谢稳定的等构替代物。本文综述了这些应变杂环可能的合成策略,包括四元环的从头构建以及氧烷构建单元的衍生化,然后是氧烷在开环和扩环反应方面的反应性,最后是选定的含氧烷天然产物的全合成。文献综述主要涵盖2015年之后的报告,但也讨论了一些被认为相关的较早的贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oxetanes: formation, reactivity and total syntheses of natural products.

Oxetanes are 4-membered cyclic monoethers which have found important applications in medicinal chemistry as polar and metabolically stable isosteric replacements for gem-dimethyl and carbonyl groups. This work reviews possible synthetic strategies towards these strained heterocycles, covering both de novo constructions of the 4-membered ring as well as derivatisations of oxetane building blocks, then reactivity of oxetanes in terms of ring-opening and ring-expansion reactions, and finally total syntheses of selected oxetane-containing natural products. The literature review primarily covers reports made after the year 2015, but a few older contributions that were considered relevant are also discussed.

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来源期刊
CiteScore
4.90
自引率
3.70%
发文量
167
审稿时长
1.4 months
期刊介绍: The Beilstein Journal of Organic Chemistry is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in organic chemistry. The journal publishes high quality research and reviews in all areas of organic chemistry, including organic synthesis, organic reactions, natural product chemistry, structural investigations, supramolecular chemistry and chemical biology.
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