Alessandro Galgani, Arnaud Mary, Francesco Lombardo, Nicola Martini, Marco Scotto, Gloria Tognoni, Gabriele Siciliano, Roberto Ceravolo, Filippo S. Giorgi, Michael T. Heneka
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LC integrity was assessed by MRI, and plasma soluble TAMs (Tyro3, Axl, and MerTK) receptor levels were measured by enzyme-linked immunosorbent assay (ELISA).</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>We found that plasma levels of the soluble TAMs receptor Axl were correlated with LC rostral degeneration in the whole cohort (<i>p</i> = 0.007), as well as in the AD+ group (<i>p</i> = 0.017), but not in the AD– group.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>These results uncover a new relationship between peripheric markers of inflammation and central early AD neurodegeneration.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>In Alzheimer's disease, no link between locus coeruleus degeneration and microglial activation was reported.</li>\n \n <li>Plasma Axl, Tyro3, and MerTK levels and locus coeruleus integrity were assessed in Alzheimer's disease patients.</li>\n \n <li>Locus coeruleus integrity positively correlates with plasma AXL, linked to microglia activation.</li>\n \n <li>Axl–noradrenergic signaling interplay deserves further larger longitudinal studies.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 7","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70434","citationCount":"0","resultStr":"{\"title\":\"Locus coeruleus integrity correlates with plasma soluble Axl levels in Alzheimer's disease patients\",\"authors\":\"Alessandro Galgani, Arnaud Mary, Francesco Lombardo, Nicola Martini, Marco Scotto, Gloria Tognoni, Gabriele Siciliano, Roberto Ceravolo, Filippo S. Giorgi, Michael T. Heneka\",\"doi\":\"10.1002/alz.70434\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> INTRODUCTION</h3>\\n \\n <p>Locus coeruleus (LC) is one of the earliest structures altered in Alzheimer's disease (AD). Inflammation is also now considered critical in AD pathology, early stage included. However, no association between LC degeneration and the peripheral inflammation has been reported yet.</p>\\n </section>\\n \\n <section>\\n \\n <h3> METHODS</h3>\\n \\n <p>A cohort of 102 patients was studied for which both magnetic resonance imaging (MRI) scans and blood samples were available. 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Locus coeruleus integrity correlates with plasma soluble Axl levels in Alzheimer's disease patients
INTRODUCTION
Locus coeruleus (LC) is one of the earliest structures altered in Alzheimer's disease (AD). Inflammation is also now considered critical in AD pathology, early stage included. However, no association between LC degeneration and the peripheral inflammation has been reported yet.
METHODS
A cohort of 102 patients was studied for which both magnetic resonance imaging (MRI) scans and blood samples were available. LC integrity was assessed by MRI, and plasma soluble TAMs (Tyro3, Axl, and MerTK) receptor levels were measured by enzyme-linked immunosorbent assay (ELISA).
RESULTS
We found that plasma levels of the soluble TAMs receptor Axl were correlated with LC rostral degeneration in the whole cohort (p = 0.007), as well as in the AD+ group (p = 0.017), but not in the AD– group.
DISCUSSION
These results uncover a new relationship between peripheric markers of inflammation and central early AD neurodegeneration.
Highlights
In Alzheimer's disease, no link between locus coeruleus degeneration and microglial activation was reported.
Plasma Axl, Tyro3, and MerTK levels and locus coeruleus integrity were assessed in Alzheimer's disease patients.
Locus coeruleus integrity positively correlates with plasma AXL, linked to microglia activation.
Axl–noradrenergic signaling interplay deserves further larger longitudinal studies.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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