酶免疫分析法检测急性恶性疟原虫抗原。

European Journal of Clinical Microbiology Pub Date : 1987-10-01 DOI:10.1007/BF02014260

B Fortier, P Delplace, J F Dubremetz, F Ajana, A Vernes

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引用次数: 5

摘要

采用酶免疫法对31例急性疟疾患者的培养上清和血清中相应的外显抗原进行检测，获得了一种50 kDa恶性疟原虫抗原表位特异性单克隆抗体。该试验对恶性疟原虫具有特异性，似乎不受菌株限制。0.001%以下可检出寄生虫血症。

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Enzyme immunoassay for detection of antigen in acute Plasmodium falciparum malaria.

A monoclonal antibody specific for an epitope of a 50 kDa Plasmodium falciparum antigen was used in an enzyme immunoassay for detection of the corresponding exo-antigen in culture supernatant and in the sera of 31 patients suffering from acute malaria. The assay was specific for Plasmodium falciparum and did not appear to be strain restricted. A parasitaemia level below 0.001% could be detected.

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European Journal of Clinical Microbiology

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