Debra A. Fleischman, Konstantinos Arfanakis, Sue E. Leurgans, Arnold M. Evia, Melissa Lamar, Alifiya Kapasi, S. Duke Han, Victoria N. Poole, Maude Wagner, David A. Bennett, Lisa L. Barnes
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Barnes","doi":"10.1002/alz.70430","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>ARTS, an in vivo marker of cerebral arteriolosclerosis, may identify older individuals at risk of mild cognitive impairment (MCI), dementia, and stroke due to cerebral small vessel disease, but deeper characterization in a large, diverse sample is needed.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>Associations between ARTS and incident MCI, dementia, and stroke, and with several common vascular risk factors, were examined in 1226 older adults without dementia and within White (<i>n</i> = 707), Black (<i>n</i> = 400), and Latino (<i>n</i> = 110) subgroups.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Higher ARTS score was associated (all <i>p</i>s < 0.01) with incident MCI (hazard ratio [HR] = 1.29), dementia (HR = 1.33), and stroke (HR = 1.52) and with diastolic/systolic blood pressure, self-reported hypertension, claudication, congestive heart failure, smoking, and glomerular filtration rate in the combined sample. 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ARTS is associated with vascular risk factors, MCI, dementia, and stroke
INTRODUCTION
ARTS, an in vivo marker of cerebral arteriolosclerosis, may identify older individuals at risk of mild cognitive impairment (MCI), dementia, and stroke due to cerebral small vessel disease, but deeper characterization in a large, diverse sample is needed.
METHODS
Associations between ARTS and incident MCI, dementia, and stroke, and with several common vascular risk factors, were examined in 1226 older adults without dementia and within White (n = 707), Black (n = 400), and Latino (n = 110) subgroups.
RESULTS
Higher ARTS score was associated (all ps < 0.01) with incident MCI (hazard ratio [HR] = 1.29), dementia (HR = 1.33), and stroke (HR = 1.52) and with diastolic/systolic blood pressure, self-reported hypertension, claudication, congestive heart failure, smoking, and glomerular filtration rate in the combined sample. Results varied across racial and ethnic groups.
DISCUSSION
ARTS has utility as an in vivo marker of cerebral arteriolosclerosis and risk of MCI, dementia, and stroke.
Highlights
ARTS score, an in vivo marker of cerebral arteriolosclerosis, was associated with incident mild cognitive impairment (MCI), dementia, and stroke in a diverse sample.
ARTS score was associated with incident dementia in the non-Latino (NL) White and NL Black subgroups separately.
ARTS score was associated with incident MCI in the NL Black subgroup.
Common vascular risk factors were associated with ARTS score, consistent with ex vivo studies.
ARTS has utility as a marker for the risk of MCI, dementia, and stroke.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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