益生菌和运动对预防与昼夜节律紊乱相关的神经退行性疾病的影响：关注肠-脑轴

IF 4.8 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Bioscience Pub Date : 2025-06-25 DOI:10.1016/j.fbio.2025.107147

Xinrong Gong , Yili Chen , Youmeng Chen , Changxi Chen , Xin Zhang

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引用次数: 0

摘要

昼夜节律紊乱越来越被认为是神经退行性疾病（NDs）发生和发展的一个促进因素。新出现的证据强调了肠道微生物群在通过肠-脑轴（GBA）调节脑功能中的关键作用，特别是在调节神经炎症和胶质细胞稳态方面。益生菌可以重塑肠道微生物组成，恢复微生物稳态，促进有益微生物代谢物的产生，如短链脂肪酸（SCFAs）和色氨酸衍生化合物，对维持大脑健康起着至关重要的作用。本文综述了益生菌的神经保护作用，重点介绍了它们在调节GBA和胶质细胞中的作用。我们还讨论了将益生菌与运动结合作为缓解昼夜节律相关神经退行性变的策略的协同潜力，为其在NDs中的预防作用提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The effects of probiotics and exercise on preventing neurodegenerative diseases associated with circadian rhythm disruption: Focus on gut-brain axis

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The effects of probiotics and exercise on preventing neurodegenerative diseases associated with circadian rhythm disruption: Focus on gut-brain axis

Circadian rhythm disruption is increasingly recognized as a contributing factor in the onset and progression of neurodegenerative diseases (NDs). Emerging evidence highlights the critical role of the gut microbiota in regulating brain function via the gut-brain axis (GBA), particularly in modulating neuroinflammation and glial cell homeostasis. Probiotics can remodel the gut microbial composition, restore microbial homeostasis, and promote the production of beneficial microbial metabolites, such as short-chain fatty acids (SCFAs) and tryptophan-derived compounds, which play vital roles in maintaining brain health. This review explores the neuroprotective effects of probiotics, emphasizing their role in modulating the GBA and glial cells. We also discuss the synergistic potential of combining probiotics with exercise as a strategy to mitigate circadian rhythm-related neurodegeneration, providing new insights into their preventive role in NDs.

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来源期刊

Food Bioscience Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

6.40

自引率

5.80%

发文量

671

审稿时长

27 days

期刊介绍： Food Bioscience is a peer-reviewed journal that aims to provide a forum for recent developments in the field of bio-related food research. The journal focuses on both fundamental and applied research worldwide, with special attention to ethnic and cultural aspects of food bioresearch.