综合多组学方法提高细针穿刺对细胞学不确定甲状腺结节的诊断准确性。

IF 3 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

Diagnostics Pub Date : 2025-06-13 DOI:10.3390/diagnostics15121506

Monia Bordoni, Nairus Aboud, Francesca Silvetti, Augusto Taccaliti, Giancarlo Balercia, Gianmaria Salvio

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引用次数: 0

摘要

在接受颈部超声检查（US）的人群中，高达68%的人意外发现甲状腺结节，而细针穿刺（FNA）是目前区分恶性和良性病变的金标准。不幸的是，三分之一的FNAs被归类为不确定，需要手术才能确诊。由于在不到一半的手术标本中观察到恶性肿瘤，这导致不必要手术的高费用和健康风险。这篇叙述性综述旨在描述最具创新性的多组学方法技术，包括基因组学、蛋白质组学和代谢组学，旨在使不确定甲状腺结节的术前评估更准确。详细描述了这些技术的优点和缺点，并提供了多组方法的SWOT（优势，劣势，机会和威胁）分析。

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Towards an Integrated Multi-Omic Approach to Improve the Diagnostic Accuracy of Fine-Needle Aspiration in Thyroid Nodules with Indeterminate Cytology.

Thyroid nodules are accidentally found in up to 68% of people undergoing neck ultrasound (US) examination, and fine needle aspiration (FNA) is the current gold standard to discriminate between malignancy and benign lesions. Unfortunately, one-third of FNAs are classified as indeterminate, requiring surgery for definitive diagnosis. This leads to high costs and health risks of unnecessary procedures, since malignancies are observed in less than half of operative specimens. This narrative review aims to describe the most innovative multi-omics approach techniques, including genomics, proteomics, and metabolomics, aimed at making the preoperative evaluation of indeterminate thyroid nodules more accurate. The advantages and disadvantages of the techniques are described in detail, and a SWOT (strengths, weaknesses, opportunities, and threats) analysis of the multi-omic approach is provided.

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来源期刊

Diagnostics Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry

CiteScore

4.70

自引率

8.30%

发文量

2699

审稿时长

19.64 days

期刊介绍： Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.