Laura Stankeviciute, Núria Tort-Colet, Ana Fernández-Arcos, Gonzalo Sánchez-Benavides, Carolina Minguillón, Karine Fauria, Sebastian Camillo Holst, Pilar Garcés, Thomas Mueggler, Henrik Zetterberg, Kaj Blennow, Álex Iranzo, Marc Suárez-Calvet, Juan Domingo Gispert, José Luis Molinuevo, Oriol Grau-Rivera, for the ALFA Study
{"title":"认知未受损成年人客观睡眠指标与大脑结构之间的关联：与性别和阿尔茨海默病生物标志物的相互作用","authors":"Laura Stankeviciute, Núria Tort-Colet, Ana Fernández-Arcos, Gonzalo Sánchez-Benavides, Carolina Minguillón, Karine Fauria, Sebastian Camillo Holst, Pilar Garcés, Thomas Mueggler, Henrik Zetterberg, Kaj Blennow, Álex Iranzo, Marc Suárez-Calvet, Juan Domingo Gispert, José Luis Molinuevo, Oriol Grau-Rivera, for the ALFA Study","doi":"10.1002/alz.70353","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>Sleep disturbances are prevalent in Alzheimer's disease (AD), probably emerging during its preclinical stage. Poor subjective sleep quality is linked to reduced brain volume and cortical thickness (CTh), but associations with objective sleep measures, particularly regarding sex and AD pathology, remain unclear.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>We characterized 171 cognitively unimpaired adults from the ALzheimer and FAmilies (ALFA) Sleep study using actigraphy, MRI, amyloid beta 42/40, and phosphorylated tau at threonine 181 in cerebrospinal fluid.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Lower sleep efficiency, higher wake after sleep onset (WASO), and sleep fragmentation were associated with lower CTh in the medial temporal lobe and other regions linked with AD and sleep disruption, even after adjusting for AD biomarkers. Sex and AD biomarkers modified these associations, with longer WASO showing a stronger correlation with lower CTh in females.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>Disrupted sleep may reduce cortical integrity independently of AD biomarkers, suggesting alternative pathways. Females appear more vulnerable to impaired sleep, and AD pathology may exacerbate AD-related changes in CTh.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Poor sleep efficiency, increased WASO, and sleep fragmentation are associated with reduced CTh in regions vulnerable to early AD, independently of amyloid and tau pathology.</li>\n \n <li>In the presence of AD pathology, this relationship is altered, with A+T+ individuals exhibiting increased CTh associated with sleep disruption.</li>\n \n <li>Sex-specific effects suggest females are more vulnerable to sleep-related cortical thinning.</li>\n \n <li>These findings highlight the potential of targeting sleep as a secondary prevention strategy to preserve brain integrity and mitigate neurodegenerative processes in AD-vulnerable regions.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 6","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70353","citationCount":"0","resultStr":"{\"title\":\"Associations between objective sleep metrics and brain structure in cognitively unimpaired adults: interactions with sex and Alzheimer's biomarkers\",\"authors\":\"Laura Stankeviciute, Núria Tort-Colet, Ana Fernández-Arcos, Gonzalo Sánchez-Benavides, Carolina Minguillón, Karine Fauria, Sebastian Camillo Holst, Pilar Garcés, Thomas Mueggler, Henrik Zetterberg, Kaj Blennow, Álex Iranzo, Marc Suárez-Calvet, Juan Domingo Gispert, José Luis Molinuevo, Oriol Grau-Rivera, for the ALFA Study\",\"doi\":\"10.1002/alz.70353\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> INTRODUCTION</h3>\\n \\n <p>Sleep disturbances are prevalent in Alzheimer's disease (AD), probably emerging during its preclinical stage. Poor subjective sleep quality is linked to reduced brain volume and cortical thickness (CTh), but associations with objective sleep measures, particularly regarding sex and AD pathology, remain unclear.</p>\\n </section>\\n \\n <section>\\n \\n <h3> METHODS</h3>\\n \\n <p>We characterized 171 cognitively unimpaired adults from the ALzheimer and FAmilies (ALFA) Sleep study using actigraphy, MRI, amyloid beta 42/40, and phosphorylated tau at threonine 181 in cerebrospinal fluid.</p>\\n </section>\\n \\n <section>\\n \\n <h3> RESULTS</h3>\\n \\n <p>Lower sleep efficiency, higher wake after sleep onset (WASO), and sleep fragmentation were associated with lower CTh in the medial temporal lobe and other regions linked with AD and sleep disruption, even after adjusting for AD biomarkers. Sex and AD biomarkers modified these associations, with longer WASO showing a stronger correlation with lower CTh in females.</p>\\n </section>\\n \\n <section>\\n \\n <h3> DISCUSSION</h3>\\n \\n <p>Disrupted sleep may reduce cortical integrity independently of AD biomarkers, suggesting alternative pathways. 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Associations between objective sleep metrics and brain structure in cognitively unimpaired adults: interactions with sex and Alzheimer's biomarkers
INTRODUCTION
Sleep disturbances are prevalent in Alzheimer's disease (AD), probably emerging during its preclinical stage. Poor subjective sleep quality is linked to reduced brain volume and cortical thickness (CTh), but associations with objective sleep measures, particularly regarding sex and AD pathology, remain unclear.
METHODS
We characterized 171 cognitively unimpaired adults from the ALzheimer and FAmilies (ALFA) Sleep study using actigraphy, MRI, amyloid beta 42/40, and phosphorylated tau at threonine 181 in cerebrospinal fluid.
RESULTS
Lower sleep efficiency, higher wake after sleep onset (WASO), and sleep fragmentation were associated with lower CTh in the medial temporal lobe and other regions linked with AD and sleep disruption, even after adjusting for AD biomarkers. Sex and AD biomarkers modified these associations, with longer WASO showing a stronger correlation with lower CTh in females.
DISCUSSION
Disrupted sleep may reduce cortical integrity independently of AD biomarkers, suggesting alternative pathways. Females appear more vulnerable to impaired sleep, and AD pathology may exacerbate AD-related changes in CTh.
Highlights
Poor sleep efficiency, increased WASO, and sleep fragmentation are associated with reduced CTh in regions vulnerable to early AD, independently of amyloid and tau pathology.
In the presence of AD pathology, this relationship is altered, with A+T+ individuals exhibiting increased CTh associated with sleep disruption.
Sex-specific effects suggest females are more vulnerable to sleep-related cortical thinning.
These findings highlight the potential of targeting sleep as a secondary prevention strategy to preserve brain integrity and mitigate neurodegenerative processes in AD-vulnerable regions.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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