拉莫三嗪和抗癫痫药物治疗HLH：系统综述。

IF 3.8 2区医学 Q1 HEMATOLOGY

British Journal of Haematology Pub Date : 2025-06-22 DOI:10.1111/bjh.20221

Yaswanta K. Gummadi, Ashley E. Sutherland, Kristin M. Ikeda, Lori Connors, Luke Y. C. Chen

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引用次数: 0

摘要

据报道，拉莫三嗪和其他抗癫痫药物可引起噬血细胞淋巴组织细胞增多症（HLH）和药物性超敏反应综合征（DIHS）。HLH和DIHS具有许多独特的临床、实验室、病理表现和潜在机制；在我们的系统综述中，我们发现这两种综合征之间存在显著的临床重叠。值得注意的是，骨髓活检中出现的噬血细胞增多症虽然是支持性的，但并不是HLH诊断的专属或同义词。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Lamotrigine and anti-seizure medications in HLH: A systematic review

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Lamotrigine and anti-seizure medications in HLH: A systematic review

Lamotrigine and other anti-seizure medications have been reported to cause both haemophagocytic lympho-histiocytosis (HLH) and drug-induced hypersensitivity syndrome (DIHS). HLH and DIHS have many characteristic clinical, laboratory, pathological findings and underlying mechanisms; we identified significant clinical overlap between these two syndromes in our systematic review. Of note, the presence of haemophagocytosis on bone marrow biopsy, while supportive, is not exclusive to or synonymous with a diagnosis of HLH.

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来源期刊

British Journal of Haematology 医学-血液学

CiteScore

8.60

自引率

4.60%

发文量

565

审稿时长

1 months

期刊介绍： The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.