连续输注顺铂和5-氟尿嘧啶在结直肠癌中的应用。

Cancer treatment reports Pub Date : 1987-10-01

M R Posner, J F Belliveau, A B Weitberg, K Sabbath, M C Wiemann, F J Cummings, P Calabresi

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摘要

21例可评估的转移性结直肠癌患者接受顺铂持续输注(25mg /m2/天X 3天)和5-氟尿嘧啶单丸(400mg /m2/天X 3天)联合治疗。毒性很小。7名患者(33%)有反应。在16名未接受治疗的患者中(44%)观察到所有缓解，中位持续时间为30周。结果表明需要对这种治疗进行III期试验。

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Continuous-infusion cisplatin and bolus 5-fluorouracil in colorectal carcinoma.

Twenty-one evaluable patients with metastatic colorectal carcinoma were treated with a combination of continuous-infusion cisplatin (25 mg/m2/day X 3 days) and bolus 5-fluorouracil (400 mg/m2/day X 3 days). Toxicity was minimal. Seven patients (33%) responded. All responses were observed among the 16 previously untreated patients (44%) and lasted a median of 30 weeks. The results indicate the need for phase III trials of this treatment.

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Cancer treatment reports

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