糖尿病周围神经病变能否预测糖尿病患者的腔隙性卒中？

IF 4.6 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes & metabolism Pub Date : 2025-06-09 DOI:10.1016/j.diabet.2025.101675

Nathalie Deschamps , Nadia Sabbah , Amina Nasri , Michel Haba , Mathieu Nacher , Bertrand De Toffol

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引用次数: 0

摘要

中风是妇女死亡和成人运动障碍的主要原因。在糖尿病患者中，糖尿病周围神经病变（DPN）增加缺血性卒中的风险。这项工作的目的是测试的假设，缺血性卒中的病因模式的患者DPN可以被识别。这是一项针对卡宴综合医院缺血性脑卒中住院患者的单中心回顾性观察研究。主要目的是确定卒中机制与DPN存在之间是否存在关联。我们纳入226例患者：平均年龄64.14±15.2岁；男性占优势（62.4%）；DPN占5.8%，即糖尿病患者占14.9%。DPN与小血管病变（SVD）显著相关：校正优势比=5.08[1.17;22.14]。这些发现强调了DPN和SVD之间的共同病理生理。DPN可以为检测SVD和预防其并发症（如中风或痴呆）提供机会。

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Can diabetic peripheral neuropathy predict lacunar stroke in patients with diabetes?

Stroke is the leading-cause of death in women and motor-disability in adults. In patients with diabetes, diabetic peripheral neuropathy (DPN) increases the risk of ischemic stroke. The aim of this work was to test the hypothesis that an etiological pattern of ischemic stroke in patients with DPN can be recognized. This was a single-center retrospective observational study of patients hospitalized in Cayenne general-hospital with ischemic stroke. The primary endpoint was to determine if there is an association between the mechanism of stroke and the presence of DPN. We included 226 patients: mean age 64.14 ± 15.2 years; male predominance (62.4 %); and 5.8 % with DPN, i.e., 14.9 % of patients with diabetes. DPN was significantly associated with small-vessel disease (SVD): adjusted odds ratio=5.08 [1.17;22.14]. These findings highlight a common pathophysiology between DPN and SVD. DPN can provide a window of opportunity to detect SVD and prevent its complications like stroke or dementia.

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来源期刊

Diabetes & metabolism 医学-内分泌学与代谢

CiteScore

12.00

自引率

4.20%

发文量

审稿时长

13 days

期刊介绍： A high quality scientific journal with an international readership Official publication of the SFD, Diabetes & Metabolism, publishes high-quality papers by leading teams, forming a close link between hospital and research units. Diabetes & Metabolism is published in English language and is indexed in all major databases with its impact factor constantly progressing. Diabetes & Metabolism contains original articles, short reports and comprehensive reviews.