血液表观遗传年龄的临界加速在膝关节OA进展中的生物学重要性尚不清楚：来自骨关节炎倡议和约翰斯顿县骨关节炎项目的标本和数据

IF 7.2 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage Pub Date : 2025-06-04 DOI:10.1016/j.joca.2025.05.010

Cindy Miranda Brawner, Cassandra Sturdy, Liubov Arbeeva, Yvonne M. Golightly, Amanda E. Nelson, Matlock A. Jeffries

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引用次数: 0

摘要

衰老是骨关节炎（OA）的最大危险因素之一。虽然表观遗传学在OA中发挥作用，但以往的研究并未发现OA患者外周血表观遗传学衰老总体加速。本研究的目的是评估不同类型OA进展者和非进展者（NPs）的外周血表观遗传衰老率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Borderline acceleration in blood epigenetic age of unclear biological importance in knee OA progression: Specimens and data from the Osteoarthritis Initiative and Johnston County Osteoarthritis Project

Aging is among the strongest risk factors for osteoarthritis (OA). Although epigenetics plays a role in OA, previous studies have not found accelerated peripheral blood epigenetic aging among OA patients overall. The goal of this study was to evaluate peripheral blood epigenetic aging rates among various types of OA progressors and non-progressors (NPs).

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来源期刊

Osteoarthritis and Cartilage 医学-风湿病学

CiteScore

11.70

自引率

7.10%

发文量

802

审稿时长

52 days

期刊介绍： Osteoarthritis and Cartilage is the official journal of the Osteoarthritis Research Society International. It is an international, multidisciplinary journal that disseminates information for the many kinds of specialists and practitioners concerned with osteoarthritis.