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复活一个微型Cas9祖先用于基因组和表观基因组编辑

IF 33.1 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature biotechnology Pub Date : 2025-06-03 DOI:10.1038/s41587-025-02707-8
Gabriel L. Butterfield, Charles A. Gersbach
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引用次数: 0

摘要

CRISPR-Cas9系统的祖先蛋白——小于其著名后代的一半大小——被设计成一种有效的dna靶向工具，可以由AAV作为表观基因组编辑器传递，用于体内基因沉默。
本文章由计算机程序翻译，如有差异，请以英文原文为准。

Resurrecting a miniature Cas9 ancestor for genome and epigenome editing

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Resurrecting a miniature Cas9 ancestor for genome and epigenome editing
The ancestral protein of the CRISPR–Cas9 system — less than half the size of its famous descendant — is engineered into an effective DNA-targeting tool that can be delivered by AAV as an epigenome editor for in vivo gene silencing.
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来源期刊
Nature biotechnology
Nature biotechnology 工程技术-生物工程与应用微生物
CiteScore
63.00
自引率
1.70%
发文量
382
审稿时长
3 months
期刊介绍： Nature Biotechnology is a monthly journal that focuses on the science and business of biotechnology. It covers a wide range of topics including technology/methodology advancements in the biological, biomedical, agricultural, and environmental sciences. The journal also explores the commercial, political, ethical, legal, and societal aspects of this research. The journal serves researchers by providing peer-reviewed research papers in the field of biotechnology. It also serves the business community by delivering news about research developments. This approach ensures that both the scientific and business communities are well-informed and able to stay up-to-date on the latest advancements and opportunities in the field. Some key areas of interest in which the journal actively seeks research papers include molecular engineering of nucleic acids and proteins, molecular therapy, large-scale biology, computational biology, regenerative medicine, imaging technology, analytical biotechnology, applied immunology, food and agricultural biotechnology, and environmental biotechnology. In summary, Nature Biotechnology is a comprehensive journal that covers both the scientific and business aspects of biotechnology. It strives to provide researchers with valuable research papers and news while also delivering important scientific advancements to the business community.
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