利用n -溴琥珀酰亚胺光诱导氧化苯基氢

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-05-26 DOI:10.1016/j.tet.2025.134754

Ke Xu, Ruimin Wang, Wei Li, Yali Wang, Caifang Han

引用次数: 0

摘要

利用n-溴代琥珀酰亚胺（NBS）直接氧化苯基C(sp3)-H键生成羰基的无过渡金属方案。该氧化方案具有操作简单的特点，既不需要溶剂预处理，也不需要惰性气氛保护（N2/O2）。在优化的条件下，反应进行得很快，能得到中等到较高收率的目标产物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Photoinduced oxidation of benzylic hydrogens using N-bromosuccinimide

A transition-metal-free protocol for direct oxidation of benzylic C(sp³)-H bonds to carbonyl groups using N-bromosuccinimide (NBS) has been developed. This oxidative protocol features remarkable operational simplicity, requiring neither solvent pretreatment nor inert atmosphere protection (N₂/O₂). The reaction proceeds rapidly under optimized conditions, affording the target products in moderate to good yields.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.