合理构建具有双pH和双粘度响应的简化半花青碱荧光探针CCX-1，用于溶酶体特异性肿瘤成像。

IF 2.6 3区化学 Q2 CHEMISTRY, ANALYTICAL

Analytical Methods Pub Date : 2025-05-28 DOI:10.1039/D5AY00577A

Qingxiu Chen, Shuanglong Li, Shun Li, Peipei Tong, Ruping Li, Jiaqiang Wu, Chunli Xia and Daoyuan Chen

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引用次数: 0

摘要

合理设计了一种简化的D-π-A半菁氨酸探针CCX-1，并通过一步缩合反应合成。CCX-1对pH值和黏度变化表现出双响应荧光行为，并具有特异的溶酶体靶向能力。值得注意的是，CCX-1能够区分肿瘤和正常细胞，并在活体小鼠中实现肿瘤可视化，显示出精确癌症成像和诊断的巨大潜力。

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Rational construction of a simplified hemicyanine-based fluorescent probe CCX-1 with dual pH and viscosity response for lysosome-specific tumour imaging†

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Rational construction of a simplified hemicyanine-based fluorescent probe CCX-1 with dual pH and viscosity response for lysosome-specific tumour imaging†

A simplified D–π–A hemicyanine probe CCX-1 was rationally designed and synthesised via a one-step condensation reaction. CCX-1 exhibits dual-responsive fluorescence behavior towards pH and viscosity changes, along with specific lysosomal targeting capability. Notably, CCX-1 enables discrimination between tumor and normal cells, and tumor visualization in living mice, showing significant potential for precise cancer imaging and diagnosis.

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