原发性胸膜淋巴瘤在免疫能力的病人:诊断和治疗的挑战。

IF 3 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Carlos Silva Paredes, Juan Lauretta, Marien Semprun, Diego Rivera-Porras, María Elena Viloria, Valmore Bermúdez
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引用次数: 0

摘要

背景:原发性胸膜淋巴瘤是一种罕见的疾病,对诊断和治疗提出了挑战。病例介绍:我们报告一名65岁女性,呼吸困难、咳嗽和虚弱,无明显既往病史。胸部x线及电脑断层显示大量右侧胸腔积液。胸腔镜显示多发胸膜结节,胸膜液分析显示淋巴细胞渗出,最后,胸膜结节活检免疫组化分析证实原发性胸膜淋巴瘤诊断。讨论:就此,患者接受环磷酰胺、阿霉素、长春新碱、地塞米松、利妥昔单抗化疗8个周期,随访1年后,临床和放射学完全缓解。结论:我们得出结论,视频辅助胸腔镜和适当的组织病理学检查仍然是诊断的金标准,而R-CHOP化疗加利妥昔单抗可能是一种非常有效的治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Primary Pleural Lymphoma in an Immune-Competent Patient: A Diagnostic and Therapeutic Challenge.

Background: Primary pleural lymphoma is a rare disease posing diagnostic and therapeutic challenges. Case presentation: We present a 65-year-old woman with dyspnoea, cough, and asthenia, with no significant past medical history. Chest X-ray and computed tomography showed extensive right pleural effusion. Video-assisted thoracoscopy demonstrated multiple pleural nodules, while pleural fluid analysis revealed a lymphocytic exudate, and finally, a primary pleural lymphoma diagnosis was confirmed by immunohistochemistry analysis in pleural nodules biopsy. Discussion: In this regard, eight cycles of chemotherapy with cyclophosphamide, doxorubicin, vincristine, dexamethasone, and rituximab were indicated, and after one year of follow-up, complete clinical and radiological remission was observed. Conlusions: We conclude that video-assisted thoracoscopy with an appropriate histopathological examination remains the gold standard for diagnosis, while R-CHOP chemotherapy plus rituximab may represent a highly effective therapeutic choice.

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来源期刊
Journal of Personalized Medicine
Journal of Personalized Medicine Medicine-Medicine (miscellaneous)
CiteScore
4.10
自引率
0.00%
发文量
1878
审稿时长
11 weeks
期刊介绍: Journal of Personalized Medicine (JPM; ISSN 2075-4426) is an international, open access journal aimed at bringing all aspects of personalized medicine to one platform. JPM publishes cutting edge, innovative preclinical and translational scientific research and technologies related to personalized medicine (e.g., pharmacogenomics/proteomics, systems biology). JPM recognizes that personalized medicine—the assessment of genetic, environmental and host factors that cause variability of individuals—is a challenging, transdisciplinary topic that requires discussions from a range of experts. For a comprehensive perspective of personalized medicine, JPM aims to integrate expertise from the molecular and translational sciences, therapeutics and diagnostics, as well as discussions of regulatory, social, ethical and policy aspects. We provide a forum to bring together academic and clinical researchers, biotechnology, diagnostic and pharmaceutical companies, health professionals, regulatory and ethical experts, and government and regulatory authorities.
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