VDAC2加强了对癌症免疫的线粒体检查点

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-05-19 DOI:10.1038/s41590-025-02171-1

Katia Cosentino, Joost Verduijn, Lorenzo Galluzzi

引用次数: 0

摘要

线粒体完整性控制细胞和免疫稳态在各种病理生理设置。最近的研究结果表明，VDAC2通过抑制BAK拮抗IFNγ驱动恶性细胞线粒体通透性的能力，从而促进细胞存活和免疫逃逸。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

VDAC2 enforces a mitochondrial checkpoint to cancer immunity

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VDAC2 enforces a mitochondrial checkpoint to cancer immunity

Mitochondrial integrity controls cellular and immunological homeostasis in various pathophysiological settings. Recent findings suggest that VDAC2 antagonizes the ability of IFNγ to drive mitochondrial permeabilization in malignant cells by inhibiting BAK, thus promoting cell survival and immunoevasion.

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.