全合成中的不对称1,4加成和功能化策略。

IF 3.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2025-05-16 DOI:10.1002/chem.202501269

Shaowei Wang, Ping Lu

引用次数: 0

摘要

过渡金属催化的对映选择性1,4加成和后续功能化策略为构建2,3-二取代环烷酮提供了强有力的途径，这些环烷酮进一步成为天然产物全合成的重要中间体。这篇概念文章强调了方法发展和相关综合应用的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Asymmetric 1,4-Addition and Functionalization Strategy in Total Synthesis.

The transition-metal catalyzed enantioselective 1,4-addition and subsequent functionalization strategy provides a powerful approach to construct 2,3-disubstituted cycloalkanones, which are further utilized as important intermediates in the total synthesis of natural products. This concept article highlights recent advances in the methodology development and related synthetic application.

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

期刊介绍： Chemistry—A European Journal is a truly international journal with top quality contributions (2018 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields. Based in Europe Chemistry—A European Journal provides an excellent platform for increasing the visibility of European chemistry as well as for featuring the best research from authors from around the world. All manuscripts are peer-reviewed, and electronic processing ensures accurate reproduction of text and data, plus short publication times. The Concepts section provides nonspecialist readers with a useful conceptual guide to unfamiliar areas and experts with new angles on familiar problems. Chemistry—A European Journal is published on behalf of ChemPubSoc Europe, a group of 16 national chemical societies from within Europe, and supported by the Asian Chemical Editorial Societies. The ChemPubSoc Europe family comprises: Angewandte Chemie, Chemistry—A European Journal, European Journal of Organic Chemistry, European Journal of Inorganic Chemistry, ChemPhysChem, ChemBioChem, ChemMedChem, ChemCatChem, ChemSusChem, ChemPlusChem, ChemElectroChem, and ChemistryOpen.