靶向肽引导的缺血心肌纳米泡多模态成像及治疗冠状动脉微血管功能障碍（Adv. Healthcare Mater. 13/2025）

IF 10 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2025-05-16 DOI:10.1002/adhm.202570080

Bo Yu, Ziwei Pang, Jing Zhao, Jingyi Xue, Hsuan Lo, Tiancheng Gu, Ping Zhang, Jiawei Tian, Guo-Qing Du

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引用次数: 0

摘要

在文章2404477中，田佳伟、杜国庆等人设计了以缺血心肌靶向肽为靶标的吲哚菁绿功能化纳米泡。这些纳米气泡有效地靶向心肌细胞，并实现冠状动脉微血管功能障碍（CMD）小鼠缺血心肌的多模态（荧光、超声和光声）成像。当负载单宁酸时，这些纳米气泡可显著改善CMD小鼠的心肌缺血和纤维化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Ischemic Myocardium Targeting Peptide-Guided Nanobubbles for Multimodal Imaging and Treatment of Coronary Microvascular Dysfunction (Adv. Healthcare Mater. 13/2025)

Nanobubbles for Ischemic Myocardium

In article 2404477, Jiawei Tian, Guo-Qing Du, and co-workers designed indocyanine green-functionalized nanobubbles targeted with an ischemic myocardium-targeting peptide. These nanobubbles effectively target cardiomyocytes and enable multimodal (fluorescence, ultrasonic, and photoacoustic) imaging of ischemic myocardium in mice with coronary microvascular dysfunction (CMD). When loaded with tannic acid, these nanobubbles significantly ameliorate myocardial ischemia and fibrosis in CMD mice.

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.