Allison W Kurian, Elisha Hughes, Ryan Bernhisel, Eudora Hu, Eric C Polley, Siddhartha Yadav, Chunling Hu, Jennifer L Caswell-Jin, Esther M John, Aladdin H Shadyab, Rowan Chlebowski, Rami Nassir, Peter Kraft, Marcia L Stefanick, Fergus J Couch
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Breast Cancer Risk Modification in Women with Pathogenic Variants in BRCA1, BRCA2, ATM, CHEK2, and PALB2.
Significance: There is limited information on whether established risk factors increase breast cancer risk from PVs. In the WHI, PV carriers had no substantial (≥2-fold) increase with most risk factors, except potentially MHT in ATM or CHEK2 carriers. The results may inform counseling and research on MHT.
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