Kirusha Naidoo, Richard J Lessells, Jienchi Dorward, Mahomed Y S Moosa, Yukteshwar Sookrajh, Pravi Moodley, Paul K Drain, Nigel Garrett
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Rapid emergence of dolutegravir resistance on second-line dolutegravir-based ART.
The integrase strand transfer inhibitor, dolutegravir (DTG), is widely used in first- and second-line antiretroviral therapy (ART) regimens in South Africa. We describe an adult with virological failure on second-line tenofovir/lamivudine/dolutegravir (TLD2) and rapid emergence of DTG resistance within 3 months, while receiving rifapentine-based tuberculosis preventive therapy.
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