结构生物学的尖端工具：将AlphaFold带给人们。

IF 14 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Microbiology Pub Date : 2025-05-03 DOI:10.1016/j.tim.2025.03.014

Christoph Elfmann, Jörg Stülke

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引用次数: 0

摘要

最近，AlphaFold在基于人工智能的蛋白质和蛋白质复合体结构预测方面的应用彻底改变了生物学。在这里，我们概述了这些工具，这些工具使实验微生物学家可以在没有生物信息学或复杂计算机设备培训的情况下获得这场革命，并展示了这如何有助于获得新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cutting-edge tools for structural biology: bringing AlphaFold to the people.

The recent application of artificial intelligence-based prediction of protein and protein complex structures by AlphaFold has revolutionized biology. Here, we give an overview of the tools that make this revolution accessible to experimental microbiologists without training in bioinformatics or sophisticated computer equipment, and show how this helps to gain new insights.

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来源期刊

Trends in Microbiology 生物-生化与分子生物学

CiteScore

25.30

自引率

0.60%

发文量

193

审稿时长

6-12 weeks

期刊介绍： Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.