染色质重塑与癌症：SWI/SNF复合物的关键影响。

IF 4.2 2区生物学 Q1 GENETICS & HEREDITY

Epigenetics & Chromatin Pub Date : 2025-04-23 DOI:10.1186/s13072-025-00590-w

Fengxiang Hao, Ying Zhang, Jiayi Hou, Bin Zhao

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引用次数: 0

摘要

SWI/SNF复合物最初是在酵母中发现的，并以对交配型开关（SWI）和蔗糖非发酵（SNF）途径至关重要的突变体的研究命名。SWI/SNF复合物通过改变染色质结构，促进或抑制特定基因的表达，维持干细胞多能性，参与多种生物学过程，在调节基因表达方面发挥着关键作用。SWI/SNF复合物的突变在各种人类癌症中非常普遍，显著影响肿瘤抑制或致癌功能，并影响肿瘤的发生和进展。本文综述了ARID1A/ARID1B、PBRM1、SMARCB1和SMARCA2/SMARCA4在癌症中的作用机制、SWI/SNF复合物的免疫调节作用、其参与DNA修复途径、合成致死性以及在精确肿瘤学中的应用。

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Chromatin remodeling and cancer: the critical influence of the SWI/SNF complex.

The SWI/SNF complex was first identified in yeast and named after studies of mutants critical for the mating-type switch (SWI) and sucrose non-fermenting (SNF) pathways.The SWI/SNF complex plays a pivotal role in regulating gene expression by altering chromatin structure to promote or suppress the expression of specific genes, maintain stem cell pluripotency, and participate in various biological processes. Mutations in the SWI/SNF complex are highly prevalent in various human cancers, significantly impacting tumor suppressive or oncogenic functions and influencing tumor initiation and progression. This review focuses on the mechanisms by which ARID1A/ARID1B, PBRM1, SMARCB1, and SMARCA2/SMARCA4 contribute to cancer, the immunoregulatory roles of the SWI/SNF complex, its involvement in DNA repair pathways, synthetic lethality, and applications in precision oncology.

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来源期刊

Epigenetics & Chromatin GENETICS & HEREDITY-

CiteScore

7.00

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Epigenetics & Chromatin is a peer-reviewed, open access, online journal that publishes research, and reviews, providing novel insights into epigenetic inheritance and chromatin-based interactions. The journal aims to understand how gene and chromosomal elements are regulated and their activities maintained during processes such as cell division, differentiation and environmental alteration.