dNTP耗竭及其后：samhd1介导的病毒限制的多面性

IF 4 2区医学 Q2 VIROLOGY

Journal of Virology Pub Date : 2025-05-20 Epub Date: 2025-04-25 DOI:10.1128/jvi.00302-25

Pak-Hin Hinson Cheung, Hua Yang, Li Wu

{"title":"dNTP耗竭及其后：samhd1介导的病毒限制的多面性","authors":"Pak-Hin Hinson Cheung, Hua Yang, Li Wu","doi":"10.1128/jvi.00302-25","DOIUrl":null,"url":null,"abstract":"SAMHD1 is a dNTPase of mammalian cells. In 2011, SAMHD1 was found to be a host restriction factor against retroviruses through dNTP reduction. Recent research provides evidence that the antiviral mechanisms of SAMHD1 cannot be explained solely by its dNTPase activity. Instead, the versatility of SAMHD1-mediated restriction of various viruses suggests that its antiviral mechanisms extend beyond dNTP depletion. This explains the multifaceted and broad restriction functions of SAMHD1 that play a significant role in innate antiviral immunity.","PeriodicalId":17583,"journal":{"name":"Journal of Virology","volume":" ","pages":"e0030225"},"PeriodicalIF":4.0000,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090746/pdf/","citationCount":"0","resultStr":"{\"title\":\"dNTP depletion and beyond: the multifaceted nature of SAMHD1-mediated viral restriction.\",\"authors\":\"Pak-Hin Hinson Cheung, Hua Yang, Li Wu\",\"doi\":\"10.1128/jvi.00302-25\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"SAMHD1 is a dNTPase of mammalian cells. In 2011, SAMHD1 was found to be a host restriction factor against retroviruses through dNTP reduction. Recent research provides evidence that the antiviral mechanisms of SAMHD1 cannot be explained solely by its dNTPase activity. Instead, the versatility of SAMHD1-mediated restriction of various viruses suggests that its antiviral mechanisms extend beyond dNTP depletion. This explains the multifaceted and broad restriction functions of SAMHD1 that play a significant role in innate antiviral immunity.\",\"PeriodicalId\":17583,\"journal\":{\"name\":\"Journal of Virology\",\"volume\":\" \",\"pages\":\"e0030225\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-05-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090746/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Virology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1128/jvi.00302-25\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/25 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"VIROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Virology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1128/jvi.00302-25","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/25 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"VIROLOGY","Score":null,"Total":0}

引用次数: 0

摘要

SAMHD1是哺乳动物细胞的dntp酶。2011年，SAMHD1通过dNTP还原被发现是抗逆转录病毒的宿主限制因子。最近的研究提供证据表明SAMHD1的抗病毒机制不能仅仅通过其dNTPase活性来解释。相反，samhd1介导的多种病毒限制的多功能性表明其抗病毒机制超出了dNTP耗竭。这解释了SAMHD1在先天抗病毒免疫中发挥重要作用的多方面和广泛的限制功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

dNTP depletion and beyond: the multifaceted nature of SAMHD1-mediated viral restriction.

SAMHD1 is a dNTPase of mammalian cells. In 2011, SAMHD1 was found to be a host restriction factor against retroviruses through dNTP reduction. Recent research provides evidence that the antiviral mechanisms of SAMHD1 cannot be explained solely by its dNTPase activity. Instead, the versatility of SAMHD1-mediated restriction of various viruses suggests that its antiviral mechanisms extend beyond dNTP depletion. This explains the multifaceted and broad restriction functions of SAMHD1 that play a significant role in innate antiviral immunity.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Virology 医学-病毒学

CiteScore

10.10

自引率

7.40%

发文量

906

审稿时长

1 months

期刊介绍： Journal of Virology (JVI) explores the nature of the viruses of animals, archaea, bacteria, fungi, plants, and protozoa. We welcome papers on virion structure and assembly, viral genome replication and regulation of gene expression, genetic diversity and evolution, virus-cell interactions, cellular responses to infection, transformation and oncogenesis, gene delivery, viral pathogenesis and immunity, and vaccines and antiviral agents.