血管内皮干细胞的发育和衰老。

IF 2.5 4区医学 Q2 HEMATOLOGY

Experimental hematology Pub Date : 2025-04-29 DOI:10.1016/j.exphem.2025.104795

Fitriana N Rahmawati, Nobuyuki Takakura

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引用次数: 0

摘要

器官特异性体细胞干细胞在损伤后支持组织更新和促进再生中发挥重要作用。造血干细胞是最成熟的器官特异性体细胞之一，经常用于移植治疗。近年来，人们对包括血管内皮干细胞（VESCs）在内的其他器官特异性体细胞越来越感兴趣。我们之前报道过使用CD157和CD200作为标记从成年小鼠器官，特别是肝脏中分离VESCs。在这篇综述中，我们的目的是在我们之前的研究基础上，总结肝脏中CD157 + CD200 + vesc从胎儿期到出生后是如何发育的，它们的转录调控机制是什么，vesc如何随着年龄的增长而变化。

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Development and aging of resident endothelial stem cells in pre-existing blood vessels.

Organ-specific somatic stem cells play an important role in supporting tissue turnover and facilitating regeneration on injury. Hematopoietic stem cells are one of the most established organ-specific somatic cells that have been frequently used for transplantation therapy. Recently, there has been a growing interest in other organ-specific somatic cells, including vascular endothelial stem cells (VESCs). We have previously reported on the use of CD157 and CD200 as markers to isolate VESCs from adult mouse organs, particularly the liver. In this review, we aimed to summarize, based on our previous research, how CD157⁺CD200⁺ VESCs in the liver develop from the fetal stage to postnatal life, what transcriptional regulatory mechanisms govern them, and how VESCs change with aging.

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来源期刊

Experimental hematology 医学-血液学

CiteScore

5.30

自引率

0.00%

发文量

审稿时长

58 days

期刊介绍： Experimental Hematology publishes new findings, methodologies, reviews and perspectives in all areas of hematology and immune cell formation on a monthly basis that may include Special Issues on particular topics of current interest. The overall goal is to report new insights into how normal blood cells are produced, how their production is normally regulated, mechanisms that contribute to hematological diseases and new approaches to their treatment. Specific topics may include relevant developmental and aging processes, stem cell biology, analyses of intrinsic and extrinsic regulatory mechanisms, in vitro behavior of primary cells, clonal tracking, molecular and omics analyses, metabolism, epigenetics, bioengineering approaches, studies in model organisms, novel clinical observations, transplantation biology and new therapeutic avenues.