微生物防御中的分子臂：Argonautes和Cas4核酸酶合作

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2025-05-15 DOI:10.1016/j.molcel.2025.04.024

Sucharita Sarkar, Ian J. MacRae

引用次数: 0

摘要

在本期Molecular Cell中，Bobadilla Ugarte等人1发现cas4家族核酸酶ACE1与原核生物Argonautes合作生成引导dna，揭示了蓝藻免疫系统中专用的siDNA生物发生途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Molecular arms in microbial defense: Argonautes and Cas4 nucleases team up

In this issue of Molecular Cell, Bobadilla Ugarte et al.¹ show that ACE1, a Cas4-family nuclease, partners with prokaryotic Argonautes to generate guide DNAs, revealing a dedicated siDNA biogenesis pathway in cyanobacterial immune systems.

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.