PKR的全球翻译调控：是否不再需要PKR ？

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2025-05-15 DOI:10.1016/j.molcel.2025.04.016

Mihye Lee, Jaemin Jeon, Yoosik Kim

引用次数: 0

摘要

在本期的Molecular Cell杂志上，Lu等报道了Prkra（在人类中也称为PACT）对双链RNA刺激的保守性全局翻译抑制。Prkra直接与RNA结合，并以不依赖于Prkra的方式分离eIF2复合物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Global translational regulation by Prkra: Is PKR no longer needed?

In this issue of Molecular Cell, Lu et al.¹ report conserved global translation suppression by Prkra, also known as PACT in humans, in response to double-stranded RNA stimulation. Prkra directly binds to RNA and sequesters eIF2 complexes in a PKR-independent manner.

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.