天然产品作为永恒的补救-解锁自然的宝库。

IF 1.6 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Chimia Pub Date : 2025-04-30 DOI:10.2533/chimia.2025.241

Tamara Balsiger, Robin Teufel, Eliane Garo

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引用次数: 0

摘要

天然产品是药物的重要来源，占目前批准药物的很大比例。然而，从复杂的提取物中分离活性天然产物是具有挑战性的。为了解决这一瓶颈，我们的实验室开发了一种药物发现策略，该策略结合了内部超过2500个样品的粗植物提取物库筛选和基于高效液相色谱的活性分析方法。这个工作流程在我们小组中是常规使用的，并成功地应用于许多天然产物药物发现项目。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Natural Products as Timeless Remedies - Unlocking Nature's Treasure Trove.

Natural products are an essential source of medicines, accounting for a large proportion of approved drugs nowadays. However, the isolation of active natural products from complex extracts is challenging. To address this bottleneck, a drug discovery strategy was developed in our lab, that combines the screening of an in-house crude plant extract library of more than 2,500 samples with an HPLC-based activity profiling approach. This workflow is used routinely in our group and was successfully applied to numerous natural product drug discovery projects.

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来源期刊

Chimia 化学-化学综合

CiteScore

1.60

自引率

0.00%

发文量

144

审稿时长

2 months

期刊介绍： CHIMIA, a scientific journal for chemistry in the broadest sense covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.