{"title":"动脉自旋标记MRI识别治疗后残留脑动静脉畸形的meta分析。","authors":"Shurun Wan, Xiuyan Yang, Yudi Zhuo, Fei Chen, Peiyue He, Weibo Luo, Yi Shi, Lingqun Zhu","doi":"10.1186/s12880-025-01668-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>To use of statistical methods to assess the diagnostic value of arterial spin labeling (ASL) imaging for follow-up of treated arteriovenous malformations.</p><p><strong>Methods: </strong>We screened references from four databases, namely, the Cochrane Library, PubMed, Web of Science and Embase, that met the requirements. The methodology quality of the included studies was evaluated using the QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies-2) tool. Data pertaining to diagnostic performance were extracted, and the pooled sensitivity and specificity were calculated using a bivariate mixed-effects model.</p><p><strong>Results: </strong>We included six studies with a total of 132 patients with arteriovenous malformation (AVM). The merged sensitivity and specificity of ASL for the diagnosis of brain AVMs with incomplete occlusion after treatment were 0.94[0.86-0.98] and 0.99 [0.59-1.00], respectively. According to the SROC curve summary, the AUC was found to be 0.98 [0.96-0.99]. No significant publication bias was observed.</p><p><strong>Conclusion: </strong>While ASL does not currently match the diagnostic precision of DSA, it is instrumental in post-treatment surveillance of AVM patients. With the development of ASL technology in the future, this technique holds promise as a minimally invasive diagnostic strategy for AVMs with fewer side effects.</p><p><strong>Registration number of prospero: </strong>CRD42023422087.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9020,"journal":{"name":"BMC Medical Imaging","volume":"25 1","pages":"127"},"PeriodicalIF":2.9000,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007328/pdf/","citationCount":"0","resultStr":"{\"title\":\"Meta-analysis of arterial spin labeling MRI to identify residual cerebral arteriovenous malformations after treatment.\",\"authors\":\"Shurun Wan, Xiuyan Yang, Yudi Zhuo, Fei Chen, Peiyue He, Weibo Luo, Yi Shi, Lingqun Zhu\",\"doi\":\"10.1186/s12880-025-01668-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>To use of statistical methods to assess the diagnostic value of arterial spin labeling (ASL) imaging for follow-up of treated arteriovenous malformations.</p><p><strong>Methods: </strong>We screened references from four databases, namely, the Cochrane Library, PubMed, Web of Science and Embase, that met the requirements. The methodology quality of the included studies was evaluated using the QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies-2) tool. Data pertaining to diagnostic performance were extracted, and the pooled sensitivity and specificity were calculated using a bivariate mixed-effects model.</p><p><strong>Results: </strong>We included six studies with a total of 132 patients with arteriovenous malformation (AVM). The merged sensitivity and specificity of ASL for the diagnosis of brain AVMs with incomplete occlusion after treatment were 0.94[0.86-0.98] and 0.99 [0.59-1.00], respectively. According to the SROC curve summary, the AUC was found to be 0.98 [0.96-0.99]. No significant publication bias was observed.</p><p><strong>Conclusion: </strong>While ASL does not currently match the diagnostic precision of DSA, it is instrumental in post-treatment surveillance of AVM patients. With the development of ASL technology in the future, this technique holds promise as a minimally invasive diagnostic strategy for AVMs with fewer side effects.</p><p><strong>Registration number of prospero: </strong>CRD42023422087.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>\",\"PeriodicalId\":9020,\"journal\":{\"name\":\"BMC Medical Imaging\",\"volume\":\"25 1\",\"pages\":\"127\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-04-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007328/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMC Medical Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12880-025-01668-3\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Medical Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12880-025-01668-3","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
摘要
背景：应用统计学方法评价动脉自旋标记（ASL）成像对治疗后动静脉畸形的随访诊断价值。方法：从Cochrane Library、PubMed、Web of Science和Embase四个数据库中筛选符合要求的文献。使用QUADAS-2（诊断准确性研究质量评估-2）工具评估纳入研究的方法学质量。提取有关诊断性能的数据，并使用双变量混合效应模型计算合并敏感性和特异性。结果：我们纳入了6项研究，共132例动静脉畸形（AVM）患者。ASL诊断治疗后不完全闭塞脑动静脉畸形的合并敏感性和特异性分别为0.94[0.86-0.98]和0.99[0.59-1.00]。根据SROC曲线汇总，AUC为0.98[0.96-0.99]。未观察到显著的发表偏倚。结论：虽然目前ASL的诊断精度尚不能与DSA相匹配，但ASL在AVM患者的治疗后监测中具有重要意义。随着未来ASL技术的发展，该技术有望成为一种副作用更少的微创avm诊断策略。普洛斯彼罗注册号：CRD42023422087。临床试验号：不适用。
Meta-analysis of arterial spin labeling MRI to identify residual cerebral arteriovenous malformations after treatment.
Background: To use of statistical methods to assess the diagnostic value of arterial spin labeling (ASL) imaging for follow-up of treated arteriovenous malformations.
Methods: We screened references from four databases, namely, the Cochrane Library, PubMed, Web of Science and Embase, that met the requirements. The methodology quality of the included studies was evaluated using the QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies-2) tool. Data pertaining to diagnostic performance were extracted, and the pooled sensitivity and specificity were calculated using a bivariate mixed-effects model.
Results: We included six studies with a total of 132 patients with arteriovenous malformation (AVM). The merged sensitivity and specificity of ASL for the diagnosis of brain AVMs with incomplete occlusion after treatment were 0.94[0.86-0.98] and 0.99 [0.59-1.00], respectively. According to the SROC curve summary, the AUC was found to be 0.98 [0.96-0.99]. No significant publication bias was observed.
Conclusion: While ASL does not currently match the diagnostic precision of DSA, it is instrumental in post-treatment surveillance of AVM patients. With the development of ASL technology in the future, this technique holds promise as a minimally invasive diagnostic strategy for AVMs with fewer side effects.
期刊介绍：
BMC Medical Imaging is an open access journal publishing original peer-reviewed research articles in the development, evaluation, and use of imaging techniques and image processing tools to diagnose and manage disease.
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