哮喘患者气道循环是否影响气流阻塞？

IF 3.6 3区医学 Q1 RESPIRATORY SYSTEM

BMJ Open Respiratory Research Pub Date : 2025-04-17 DOI:10.1136/bmjresp-2024-002575

Adam Wanner

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引用次数: 0

摘要

哮喘患者气道壁增厚，气道微血管参与气道壁的重塑。有假设，但没有令人信服的证据表明，重塑的气道血管在哮喘相关的气流阻塞中具有机械作用，有助于气道壁增厚和气道狭窄。本综述研究了支持和反对这一假设的文献，并提出了关于治疗哮喘患者直接靶向气道循环的问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Does the airway circulation influence airflow obstruction in asthma?

The airway wall is thickened in asthma and the airway microvasculature participates in the remodelling. It has been assumed but not convincingly demonstrated that the remodelled airway vasculature has a mechanical role in asthma-associated airflow obstruction by contributing to the thickening of the airway wall and narrowing of the airway. This review examines the literature providing information in support of and against this assumption and raises questions about therapeutically targeting the airway circulation directly in patients with asthma.

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来源期刊

BMJ Open Respiratory Research RESPIRATORY SYSTEM-

CiteScore

6.60

自引率

2.40%

发文量

审稿时长

12 weeks

期刊介绍： BMJ Open Respiratory Research is a peer-reviewed, open access journal publishing respiratory and critical care medicine. It is the sister journal to Thorax and co-owned by the British Thoracic Society and BMJ. The journal focuses on robustness of methodology and scientific rigour with less emphasis on novelty or perceived impact. BMJ Open Respiratory Research operates a rapid review process, with continuous publication online, ensuring timely, up-to-date research is available worldwide. The journal publishes review articles and all research study types: Basic science including laboratory based experiments and animal models, Pilot studies or proof of concept, Observational studies, Study protocols, Registries, Clinical trials from phase I to multicentre randomised clinical trials, Systematic reviews and meta-analyses.