内封面：用于肿瘤微环境反应性免疫调节的酶激活正交蛋白水解嵌合体

IF 16.1 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Angewandte Chemie International Edition Pub Date : 2025-05-13 DOI:10.1002/anie.202510013

Caixia Sun, Songhan Liu, Jun Wei Lau, Hanyu Yang, Yun Chen, Bengang Xing

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引用次数: 0

摘要

Bengang Xing等人在其研究文章（e202423057）中提出了一种新的肿瘤微环境响应酶激活的可点击PROTACs，称为ENCTACs。这样的ENCTACs能够选择性地形成异双功能降解物来破坏肿瘤中的BRD4，有效地下调PD−L1用于免疫治疗。封面图描绘了酶反应后的片段偶联，实现蛋白质干预，激活抗肿瘤免疫系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Inside Front Cover: Enzyme-Activated Orthogonal Proteolysis Chimeras for Tumor Microenvironment-Responsive Immunomodulation (Angew. Chem. Int. Ed. 22/2025)

查看原文本刊更多论文

Inside Front Cover: Enzyme-Activated Orthogonal Proteolysis Chimeras for Tumor Microenvironment-Responsive Immunomodulation (Angew. Chem. Int. Ed. 22/2025)

Novel tumor microenvironment-responsive enzyme-activated clickable PROTACs, termed as ENCTACs, are presented by Bengang Xing et al. in their Research Article (e202423057). Such ENCTACs enable selective formation of heterobifunctional degraders to disrupt BRD4 in tumor, effectively downregulating PD−L1 for immunotherapy. The cover illustration depicts fragments conjugation after enzyme reaction, realizing protein intervention and activating the antitumoral immune system.

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来源期刊

Angewandte Chemie International Edition 化学-化学综合

CiteScore

26.60

自引率

6.60%

发文量

3549

审稿时长

1.5 months

期刊介绍： Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.