膀胱尿路上皮癌复发后继发性乳腺外佩吉特病伴皮肤输尿管瘘1例

Q4 Medicine

IJU Case Reports Pub Date : 2025-03-27 DOI:10.1002/iju5.70021

Masahiro Mizoguchi, Ichiro Chihara, Keisuke Sano, Tomokazu Kimura, Shuya Kandori, Hiromitsu Negoro, Bryan J. Mathis, Hitomi Kawai, Daisuke Matsubara, Hiroyuki Nishiyama

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引用次数: 0

摘要

继发性乳腺外佩吉特病（Paget's disease）的特征是肿瘤侵袭和迁移到邻近皮肤引起的表皮内癌。一例68岁男性因膀胱癌及右侧输尿管癌行根治性膀胱切除术及双侧输尿管皮肤造口术。术后随访3年计算机断层扫描及尿细胞学检查提示右侧输尿管癌复发。右侧输尿管皮瘘周围同时出现红斑及皮肤膨出，需行后腹膜镜肾输尿管切除术及口周皮肤切除术。病理显示输尿管下段尿路上皮癌伴T2病变，表皮内弥散性细胞角蛋白7+和细胞角蛋白20+ page - like细胞聚集，提示继发性Paget病。结论尿路转移后复发的上尿路上皮癌可并发继发性乳腺外皮肤佩吉特病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A Case of Secondary Extramammary Paget's Disease Surrounding a Cutaneous Ureterostoma After Recurrence of Bladder Urothelial Carcinoma

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A Case of Secondary Extramammary Paget's Disease Surrounding a Cutaneous Ureterostoma After Recurrence of Bladder Urothelial Carcinoma

Introduction

Secondary extramammary Paget's disease features intraepidermal carcinoma caused by tumor invasion and migration into adjacent skin.

Case Presentation

A 68-year-old man underwent radical cystectomy and bilateral cutaneous ureterostomy for bladder cancer and right ureteral cancer. Postoperative follow-up computed tomography and urine cytology at 3 years suggested right ureteral cancer recurrence. Contemporaneous erythema and bulging of the skin around the right ureterocutaneous fistula were observed, necessitating retroperitoneoscopic nephroureterectomy and peristomal skin resection. Pathology revealed urothelial carcinoma with T2 disease at the lower ureter, plus spreading cytokeratin 7+ and cytokeratin 20+ pagetoid cells clustered within the epidermis indicative of secondary Paget's disease.