NLRP3和NLRP1炎性小体调控的结构研究进展

IF 6.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current opinion in structural biology Pub Date : 2025-05-06 DOI:10.1016/j.sbi.2025.103057

Zhikuan Zhang, Toshiyuki Shimizu

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引用次数: 0

摘要

nod样受体（NLR）家族包括炎性小体传感器，它们是先天免疫系统中关键的细胞内模式识别受体。NLR家族成员NLRP3和NLRP1可被广泛的病原性、化学性、自源性和应激相关刺激激活。近年来，对这两种受体的功能和结构研究取得了显著进展，揭示了它们复杂而完全不同的激活和调控机制。本文综述了近年来NLRP3和NLRP1的结构研究，重点介绍了各种激活和抑制因子介导的调控步骤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent advances in structural studies of NLRP3 and NLRP1 inflammasome regulation

The NOD-like receptor (NLR) family comprises inflammasome sensors that are critical intracellular pattern recognition receptors of the innate immune system. The NLR family members NLRP3 and NLRP1 can be activated by a wide range of pathogenic, chemical, self-derived and stress-related stimuli. In recent years, remarkable progress in functional and structural studies of these two receptors have shed light on their complicated and entirely different activation and regulation mechanisms. This review focuses on recent structural studies of NLRP3 and NLRP1, emphasizing the regulatory steps mediated by various activation and inhibitory factors.

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来源期刊

Current opinion in structural biology 生物-生化与分子生物学

CiteScore

12.20

自引率

2.90%

发文量

179

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Structural Biology (COSB) aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In COSB, we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. [...] The subject of Structural Biology is divided into twelve themed sections, each of which is reviewed once a year. Each issue contains two sections, and the amount of space devoted to each section is related to its importance. -Folding and Binding- Nucleic acids and their protein complexes- Macromolecular Machines- Theory and Simulation- Sequences and Topology- New constructs and expression of proteins- Membranes- Engineering and Design- Carbohydrate-protein interactions and glycosylation- Biophysical and molecular biological methods- Multi-protein assemblies in signalling- Catalysis and Regulation