癌症相关恶病质：连接临床发现与人体研究的机制见解。

IF 29.7 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2025-04-29 DOI:10.1158/2159-8290.cd-25-0293

Kexin Koh,Rachel Scott,Elizabeth M Cespedes Feliciano,Tobias Janowitz,Marcus D Goncalves,Eileen P White,Barry J A Laird,Kerstin Haase,Mariam Jamal-Hanjani

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引用次数: 0

摘要

CAC代表了一个重要的临床未满足需求。尽管其高患病率和相关的死亡率和发病率，但目前尚无全球批准的有效治疗方法。本综述全面概述了旨在临床定义CAC和确定其潜在介质的人类研究，这些研究揭示了有效的健康干预措施。此外，我们强调正在进行的国际努力，以促进我们对CAC的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Cancer-Associated Cachexia: Bridging Clinical Findings with Mechanistic Insights in Human Studies.

CAC represents a significant clinical unmet need. Despite its high prevalence and associated mortality and morbidity, there are currently no globally approved effective therapies. This review provides a comprehensive overview of human studies aimed at defining CAC clinically and identifying mediators underlying it that are revealing effective health interventions. Furthermore, we highlight ongoing international efforts to advance our understanding of CAC.

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来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.