天然产物和铁下垂：心力衰竭管理的新方法

IF 6.7 1区医学 Q1 CHEMISTRY, MEDICINAL

Phytomedicine Pub Date : 2025-04-18 DOI:10.1016/j.phymed.2025.156783

Zeyu Zhang , Zhihua Yang , Shuai Wang , Xianliang Wang , Jingyuan Mao

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引用次数: 0

摘要

铁下垂的发现为心力衰竭的治疗带来了革命性的突破，天然产物作为药物发现的重要来源，在调节铁下垂和缓解心力衰竭症状方面正逐渐显示出非凡的潜力。除了化学合成的小分子化合物外，天然产物作为发现治疗心力衰竭的铁衰竭靶向化合物的重要来源而受到关注。目的系统总结和分析天然产物调控铁下垂通路改善心力衰竭的研究进展。方法以“心力衰竭”、“心血管疾病”、“心脏病”、“铁沉”、“天然产物”、“活性化合物”、“中药方剂”、“中药”、“针灸”等为关键词，综合检索PubMed、Web of Science、中国国家知识基础设施等权威数据库，系统综述铁沉的发病机制及其与心力衰竭的关系。我们还希望探索天然小分子化合物、中药配方和针灸疗法，以抑制铁下垂，改善心力衰竭。结果在本文中，我们不仅追溯了铁凋亡概念的演变，明确了其与其他细胞死亡形式的区别，而且建立了一个包括铁超载和系统xc-/GSH/GPX4失衡等核心机制的综合理论框架，以及多种辅助途径。在此基础上，我们创新性地将铁上吊与各种类型的心力衰竭联系起来，涵盖了经典的心力衰竭类型，并将我们的研究扩展到心律失常、主动脉瘤等心力衰竭前状态，为心力衰竭的早期干预提供了新的见解。重要的是，本文系统地整合了多种天然产物干扰铁下沉的策略，从单体化合物和生物活性成分到粗提取物，再到中药配方。此外，还包括针灸等非药物手段。结论本研究填补了对上铁与心力衰竭关系系统描述及天然产物治疗策略的空白，旨在为患者提供更多样化的治疗选择，促进心力衰竭治疗领域的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Natural products and ferroptosis: A novel approach for heart failure management

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Natural products and ferroptosis: A novel approach for heart failure management

Background

The discovery of ferroptosis has brought a revolutionary breakthrough in heart failure treatment, and natural products, as a significant source of drug discovery, are gradually demonstrating their extraordinary potential in regulating ferroptosis and alleviating heart failure symptoms. In addition to chemically synthesized small molecule compounds, natural products have attracted attention as an important source for discovering compounds that target ferroptosis in treating heart failure.

Purpose

Systematically summarize and analyze the research progress on improving heart failure through natural products' modulation of the ferroptosis pathway.

Methods

By comprehensively searching authoritative databases like PubMed, Web of Science, and China National Knowledge Infrastructure with keywords such as “heart failure”, “cardiovascular disease”, “heart disease”, “ferroptosis”, “natural products”, “active compounds”, “traditional Chinese medicine formulas”, “traditional Chinese medicine”, and “acupuncture”, we aim to systematically review the mechanism of ferroptosis and its link with heart failure. We also want to explore natural small-molecule compounds, traditional Chinese medicine formulas, and acupuncture therapies that can inhibit ferroptosis to improve heart failure.

Results

In this review, we not only trace the evolution of the concept of ferroptosis and clearly distinguish it from other forms of cell death but also establish a comprehensive theoretical framework encompassing core mechanisms such as iron overload and system xc-/GSH/GPX4 imbalance, along with multiple auxiliary pathways. On this basis, we innovatively link ferroptosis with various types of heart failure, covering classic heart failure types and extending our research to pre-heart failure conditions such as arrhythmia and aortic aneurysm, providing new insights for early intervention in heart failure. Importantly, this article systematically integrates multiple strategies of natural products for interfering with ferroptosis, ranging from monomeric compounds and bioactive components to crude extracts and further to traditional Chinese medicine formulae. In addition, non-pharmacological means such as acupuncture are also included.

Conclusion

This study fills the gap in the systematic description of the relationship between ferroptosis and heart failure and the therapeutic strategies of natural products, aiming to provide patients with more diverse treatment options and promote the development of the heart failure treatment field.

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来源期刊

Phytomedicine 医学-药学

CiteScore

10.30

自引率

5.10%

发文量

670

审稿时长

91 days

期刊介绍： Phytomedicine is a therapy-oriented journal that publishes innovative studies on the efficacy, safety, quality, and mechanisms of action of specified plant extracts, phytopharmaceuticals, and their isolated constituents. This includes clinical, pharmacological, pharmacokinetic, and toxicological studies of herbal medicinal products, preparations, and purified compounds with defined and consistent quality, ensuring reproducible pharmacological activity. Founded in 1994, Phytomedicine aims to focus and stimulate research in this field and establish internationally accepted scientific standards for pharmacological studies, proof of clinical efficacy, and safety of phytomedicines.