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干扰GPX4降解

IF 12.9 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Nature chemical biology Pub Date : 2025-04-25 DOI:10.1038/s41589-025-01873-9
Jing Li, Yuhan Zhou, Weimin Wang
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引用次数: 0

摘要

诱导肿瘤铁下垂是一种增强肿瘤免疫治疗的潜在策略。最近的一项研究表明，响应IFNγ刺激的psat1介导的GPX4羟基化阻碍了肿瘤铁凋亡，而破坏PSAT1-GPX4相互作用可以提高癌症免疫治疗的疗效。
本文章由计算机程序翻译，如有差异，请以英文原文为准。

Interfering with GPX4 degradation

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Interfering with GPX4 degradation
Inducing tumoral ferroptosis is a potential strategy for augmenting cancer immunotherapy. A recent study reveals that PSAT1-mediated GPX4 hydroxylation in response to IFNγ stimulation impedes tumoral ferroptosis, whereas disrupting the PSAT1–GPX4 interaction can improve the efficacy of cancer immunotherapy.
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来源期刊
Nature chemical biology
Nature chemical biology 生物-生化与分子生物学
CiteScore
23.90
自引率
1.40%
发文量
238
审稿时长
12 months
期刊介绍： Nature Chemical Biology stands as an esteemed international monthly journal, offering a prominent platform for the chemical biology community to showcase top-tier original research and commentary. Operating at the crossroads of chemistry, biology, and related disciplines, chemical biology utilizes scientific ideas and approaches to comprehend and manipulate biological systems with molecular precision. The journal embraces contributions from the growing community of chemical biologists, encompassing insights from chemists applying principles and tools to biological inquiries and biologists striving to comprehend and control molecular-level biological processes. We prioritize studies unveiling significant conceptual or practical advancements in areas where chemistry and biology intersect, emphasizing basic research, especially those reporting novel chemical or biological tools and offering profound molecular-level insights into underlying biological mechanisms. Nature Chemical Biology also welcomes manuscripts describing applied molecular studies at the chemistry-biology interface due to the broad utility of chemical biology approaches in manipulating or engineering biological systems. Irrespective of scientific focus, we actively seek submissions that creatively blend chemistry and biology, particularly those providing substantial conceptual or methodological breakthroughs with the potential to open innovative research avenues. The journal maintains a robust and impartial review process, emphasizing thorough chemical and biological characterization.
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