Palladium-catalyzed aminocarbonylation of vinyl bromides with isocyanides for the synthesis of α,β-unsaturated amides

A palladium-catalyzed aminocarbonylation of vinyl bromides with isocyanides was developed, which provides the α,β-unsaturated amides in moderated to good yields. Both α- and β-bromoalkenes could be applied in this method and gave the corresponding linear or branched unsaturated amides with single configuration. It provided an efficient and facile method for the synthesis of α,β-unsaturated amides from readily available feedstocks.