封面：具有柔性药物负载的天然igg的位点特异性修饰（ChemBioChem 8/2025）

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

ChemBioChem Pub Date : 2025-04-18 DOI:10.1002/cbic.202580801

Jöri E. Wehrmüller, Julia C. Frei, Torsten Hechler, Michael Kulke, Andreas Pahl, Martin Béhé, Roger Schibli, Philipp R. Spycher

{"title":"封面：具有柔性药物负载的天然igg的位点特异性修饰（ChemBioChem 8/2025）","authors":"Jöri E. Wehrmüller, Julia C. Frei, Torsten Hechler, Michael Kulke, Andreas Pahl, Martin Béhé, Roger Schibli, Philipp R. Spycher","doi":"10.1002/cbic.202580801","DOIUrl":null,"url":null,"abstract":"<p>The cover shows the direct and site-specific modification of a native antibody and the generation of an antibody-conjugate using click-chemistry. First, the positively-charged peptide (shown in yellow) carrying a functional group (highlighted in orange) is conjugated to the antibody by microbial transglutaminase followed by a click-reaction with a functional payload to generate the antibody-conjugate. More details can be found in article 10.1002/cbic.202400511 by Roger Schibli, Philipp R. Spycher, and co-workers. Illustration created by Bara Krautz.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure>\n </p>","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":"26 8","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cbic.202580801","citationCount":"0","resultStr":"{\"title\":\"Front Cover: Site-Specific Modification of Native IgGs with Flexible Drug-Load (ChemBioChem 8/2025)\",\"authors\":\"Jöri E. Wehrmüller, Julia C. Frei, Torsten Hechler, Michael Kulke, Andreas Pahl, Martin Béhé, Roger Schibli, Philipp R. Spycher\",\"doi\":\"10.1002/cbic.202580801\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The cover shows the direct and site-specific modification of a native antibody and the generation of an antibody-conjugate using click-chemistry. First, the positively-charged peptide (shown in yellow) carrying a functional group (highlighted in orange) is conjugated to the antibody by microbial transglutaminase followed by a click-reaction with a functional payload to generate the antibody-conjugate. More details can be found in article 10.1002/cbic.202400511 by Roger Schibli, Philipp R. Spycher, and co-workers. Illustration created by Bara Krautz.\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure>\\n </p>\",\"PeriodicalId\":140,\"journal\":{\"name\":\"ChemBioChem\",\"volume\":\"26 8\",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-04-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cbic.202580801\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ChemBioChem\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/cbic.202580801\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemBioChem","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cbic.202580801","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

封面展示了天然抗体的直接和位点特异性修饰，以及使用点击化学产生抗体偶联物。首先，带正电荷的肽（黄色显示）携带一个功能基团（橙色突出显示），通过微生物谷氨酰胺转酶与抗体结合，然后与功能负载进行点击反应，产生抗体偶联物。更多细节可以在第10.1002/ cic条中找到。Roger Schibli, Philipp R. Spycher及其同事。插图由Bara Krautz创作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Front Cover: Site-Specific Modification of Native IgGs with Flexible Drug-Load (ChemBioChem 8/2025)

查看原文本刊更多论文

Front Cover: Site-Specific Modification of Native IgGs with Flexible Drug-Load (ChemBioChem 8/2025)

The cover shows the direct and site-specific modification of a native antibody and the generation of an antibody-conjugate using click-chemistry. First, the positively-charged peptide (shown in yellow) carrying a functional group (highlighted in orange) is conjugated to the antibody by microbial transglutaminase followed by a click-reaction with a functional payload to generate the antibody-conjugate. More details can be found in article 10.1002/cbic.202400511 by Roger Schibli, Philipp R. Spycher, and co-workers. Illustration created by Bara Krautz.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

ChemBioChem 生物-生化与分子生物学

CiteScore

6.10

自引率

3.10%

发文量

407

审稿时长

1 months

期刊介绍： ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).