氟化吡咯烷酮衍生物的锅内经济合成

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-04-14 DOI:10.1002/adsc.202500209

Lidia Prieto, Marcos Escolano, Daniel Gaviña, Luis Paredes-Soler, Santiago Díaz Oltra, Maria Sanchez-Rosello, Carlos del Pozo

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引用次数: 0

摘要

以氟化烯胺和脂肪族共轭酮为原料合成了一类新的氟化二氢吡咯里嗪酮类化合物。该反应包括一个交叉复分解反应，然后是串联环芳构化/烯胺水解/分子内Friedel-Crafts烷基化序列。考虑到它由四个连续的反应组成，这种锅经济过程的产率很高（35-67%）。芳香烯酮也是这个方案的好伙伴，尽管在这种情况下，交叉复分解反应必须在一个单独的步骤中进行。

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Pot-Economical Synthesis of Fluorinated Pyrrolizinone Derivatives

A new family of fluorinated dihydropyrrolizinones has been synthesized starting from fluorinated enamino amides and aliphatic conjugated ketones. The reaction comprises a cross metathesis reaction followed by a tandem cycloaromatization/ enamine hydrolysis/ intramolecular Friedel-Crafts alkylation sequence. This pot-economical process takes place in good yields (35-67%), taking into account that it consists of four consecutive reactions. Aromatic enones are also good partners for this protocol although, in this case, the cross metathesis reaction has to be performed in a separated step.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.