无需选择性15N标记的氢键低分子催化剂-底物中间体中1H， 15N相关性的高效检测

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-04-11 DOI:10.1039/d5cc00537j

Christian L. Scholtes, Julian Ilgen, Ruth M. Gschwind

{"title":"无需选择性15N标记的氢键低分子催化剂-底物中间体中1H， 15N相关性的高效检测","authors":"Christian L. Scholtes, Julian Ilgen, Ruth M. Gschwind","doi":"10.1039/d5cc00537j","DOIUrl":null,"url":null,"abstract":"To date, SOFAST approaches have generally been limited to biomolecules. We present the applicability of SOFAST-HMQC techniques to small molecules in the slow-tumbling regime offering a time-efficient characterization of catalyst substrate hydrogen bonds with nitrogen at natural abundance. This extends NMR access to a broader range of catalyst substrate combinations.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"5 1","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Efficient detection of 1H, 15N correlations in hydrogen bonded low molecular catalyst–substrate intermediates without selective 15N-labelling\",\"authors\":\"Christian L. Scholtes, Julian Ilgen, Ruth M. Gschwind\",\"doi\":\"10.1039/d5cc00537j\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"To date, SOFAST approaches have generally been limited to biomolecules. We present the applicability of SOFAST-HMQC techniques to small molecules in the slow-tumbling regime offering a time-efficient characterization of catalyst substrate hydrogen bonds with nitrogen at natural abundance. This extends NMR access to a broader range of catalyst substrate combinations.\",\"PeriodicalId\":67,\"journal\":{\"name\":\"Chemical Communications\",\"volume\":\"5 1\",\"pages\":\"\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-04-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical Communications\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1039/d5cc00537j\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d5cc00537j","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

迄今为止，SOFAST方法通常仅限于生物分子。我们提出了SOFAST-HMQC技术在小分子慢滚状态下的适用性，提供了催化剂底物与天然丰度的氮氢键的时间效率表征。这将核磁共振扩展到更广泛的催化剂底物组合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Efficient detection of 1H, 15N correlations in hydrogen bonded low molecular catalyst–substrate intermediates without selective 15N-labelling

查看原文本刊更多论文

Efficient detection of 1H, 15N correlations in hydrogen bonded low molecular catalyst–substrate intermediates without selective 15N-labelling

To date, SOFAST approaches have generally been limited to biomolecules. We present the applicability of SOFAST-HMQC techniques to small molecules in the slow-tumbling regime offering a time-efficient characterization of catalyst substrate hydrogen bonds with nitrogen at natural abundance. This extends NMR access to a broader range of catalyst substrate combinations.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.